COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS
The objectives of this study were to compare the clinical effects and glycemia induced by medetomidine and xylazine in healthy cats and to demonstrate the reversal of the effects by atipamezole. A prospective blinded randomized experimental trial was used with twenty-four healthy adult cats. The ani...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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University of Western Sao Paulo, UNOESTE
2012-02-01
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| Series: | Colloquium Agrariae |
| Subjects: | |
| Online Access: | http://revistas.unoeste.br/index.php/ca/article/view/496 |
| _version_ | 1818615146067525632 |
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| author | Cleber Salesse Cardoso Elisa Bacco Jorge Aline Bozzetto dos Santos João Paulo Silva Smerdel Luis Roberto Almeida Gabriel Filho Silvia Franco Andrade |
| author_facet | Cleber Salesse Cardoso Elisa Bacco Jorge Aline Bozzetto dos Santos João Paulo Silva Smerdel Luis Roberto Almeida Gabriel Filho Silvia Franco Andrade |
| author_sort | Cleber Salesse Cardoso |
| collection | DOAJ |
| description | The objectives of this study were to compare the clinical effects and glycemia induced by medetomidine and xylazine in healthy cats and to demonstrate the reversal of the effects by atipamezole. A prospective blinded randomized experimental trial was used with twenty-four healthy adult cats. The animals were allocated into 4 groups of 6 animals each to receive by intramuscular route (IM): Group M (medetomidine - 50 μg/ kg); Group X (xylazine - 1.1 mg/kg); Group MA (medetomidine - 50 μg/kg and 60 minutes later atipamezole - 0.2 mg/kg); Group XA (xylazine - 1.1 mg/kg and 60 minutes later atipamezole - 0.2 mg/kg). Rectal temperature, respiratory rate, heart rate, systolic arterial pressure, electrocardiogram, intraocular pressure, degree of sedation were measured at 0, 30, 60, 120 and 180 minutes, and the serum glucose concentration was measured at 0, 60, 120 and 180 minutes. The xylazine at a dose of 1.1 mg/kg and medetomidine at a dose of 50 μg/kg (both intramuscular) induced hypothermia, decreased heart rate, respiration and blood pressure and also 1st-degree A-V block in some cats, but it did not interfere significantly with intraocular pressure. The medetomidine induced a more pronounced hypothermia, sedation and hyperglycemia than xylazine in cats. The atipamezole was an excellent antagonist of the effects induced by medetomidine and xylazine in cats. Also, it did not interfere with the intraocular pressure values. |
| first_indexed | 2024-12-16T16:29:16Z |
| format | Article |
| id | doaj.art-387a014f83a84c569f62cf3280735a80 |
| institution | Directory Open Access Journal |
| issn | 1809-8215 |
| language | Portuguese |
| last_indexed | 2024-12-16T16:29:16Z |
| publishDate | 2012-02-01 |
| publisher | University of Western Sao Paulo, UNOESTE |
| record_format | Article |
| series | Colloquium Agrariae |
| spelling | doaj.art-387a014f83a84c569f62cf3280735a802022-12-21T22:24:38ZporUniversity of Western Sao Paulo, UNOESTEColloquium Agrariae1809-82152012-02-0171COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATSCleber Salesse Cardoso0Elisa Bacco Jorge1Aline Bozzetto dos Santos2João Paulo Silva Smerdel3Luis Roberto Almeida Gabriel Filho4Silvia Franco Andrade5UNOESTEUnoesteUnoesteUnoesteUnoesteUNOESTEThe objectives of this study were to compare the clinical effects and glycemia induced by medetomidine and xylazine in healthy cats and to demonstrate the reversal of the effects by atipamezole. A prospective blinded randomized experimental trial was used with twenty-four healthy adult cats. The animals were allocated into 4 groups of 6 animals each to receive by intramuscular route (IM): Group M (medetomidine - 50 μg/ kg); Group X (xylazine - 1.1 mg/kg); Group MA (medetomidine - 50 μg/kg and 60 minutes later atipamezole - 0.2 mg/kg); Group XA (xylazine - 1.1 mg/kg and 60 minutes later atipamezole - 0.2 mg/kg). Rectal temperature, respiratory rate, heart rate, systolic arterial pressure, electrocardiogram, intraocular pressure, degree of sedation were measured at 0, 30, 60, 120 and 180 minutes, and the serum glucose concentration was measured at 0, 60, 120 and 180 minutes. The xylazine at a dose of 1.1 mg/kg and medetomidine at a dose of 50 μg/kg (both intramuscular) induced hypothermia, decreased heart rate, respiration and blood pressure and also 1st-degree A-V block in some cats, but it did not interfere significantly with intraocular pressure. The medetomidine induced a more pronounced hypothermia, sedation and hyperglycemia than xylazine in cats. The atipamezole was an excellent antagonist of the effects induced by medetomidine and xylazine in cats. Also, it did not interfere with the intraocular pressure values.http://revistas.unoeste.br/index.php/ca/article/view/496medetomidinexylazineatipamezolecats. |
| spellingShingle | Cleber Salesse Cardoso Elisa Bacco Jorge Aline Bozzetto dos Santos João Paulo Silva Smerdel Luis Roberto Almeida Gabriel Filho Silvia Franco Andrade COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS Colloquium Agrariae medetomidine xylazine atipamezole cats. |
| title | COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS |
| title_full | COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS |
| title_fullStr | COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS |
| title_full_unstemmed | COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS |
| title_short | COMPARATIVE STUDY OF THE EFFECTS OF MEDETOMIDINE AND XYLAZINE IN CATS |
| title_sort | comparative study of the effects of medetomidine and xylazine in cats |
| topic | medetomidine xylazine atipamezole cats. |
| url | http://revistas.unoeste.br/index.php/ca/article/view/496 |
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