Stress Granules and Neurodegenerative Disorders: A Scoping Review
Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent pre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.650740/full |
| _version_ | 1818407277918420992 |
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| author | Mohammad Reza Asadi Mohammad Reza Asadi Marziyeh Sadat Moslehian Hani Sabaie Abbas Jalaiei Soudeh Ghafouri-Fard Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh |
| author_facet | Mohammad Reza Asadi Mohammad Reza Asadi Marziyeh Sadat Moslehian Hani Sabaie Abbas Jalaiei Soudeh Ghafouri-Fard Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh |
| author_sort | Mohammad Reza Asadi |
| collection | DOAJ |
| description | Cytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent presence can affect their interactions with pathological aggregations and increase the degenerative effects. SGs involved in RNA mechanisms are important factors in the pathophysiology of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal degeneration (FTD), and Alzheimer's diseases (AD). Although many studies have been performed in the field of SGs and neurodegenerative disorders, so far, no systematic studies have been executed in this field. The purpose of this study is to provide a comprehensive perspective of all studies about the role of SGs in the pathogenesis of neurodegenerative disorders with a focus on the protein ingredients of these granules. This scoping review is based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted until December 2020. Publications were screened independently by two reviewers and quantitative and qualitative analysis was performed on the extracted data. Bioinformatics analysis was used to plot the network and predict interprotein interactions. In addition, GO analysis was performed. A total of 48 articles were identified that comply the inclusion criteria. Most studies on neurodegenerative diseases have been conducted on ALS, AD, and FTD using human post mortem tissues. Human derived cell line studies have been used only in ALS. A total 29 genes of protein components of SGs have been studied, the most important of which are TDP-43, TIA-1, PABP-1. Bioinformatics studies have predicted 15 proteins to interact with the protein components of SGs, which may be the constituents of SGs. Understanding the interactions between SGs and pathological aggregations in neurodegenerative diseases can provide new targets for treatment of these disorders. |
| first_indexed | 2024-12-14T09:25:17Z |
| format | Article |
| id | doaj.art-387ad6460e9847fda072b33654c5b52b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T09:25:17Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-387ad6460e9847fda072b33654c5b52b2022-12-21T23:08:13ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-06-011310.3389/fnagi.2021.650740650740Stress Granules and Neurodegenerative Disorders: A Scoping ReviewMohammad Reza Asadi0Mohammad Reza Asadi1Marziyeh Sadat Moslehian2Hani Sabaie3Abbas Jalaiei4Soudeh Ghafouri-Fard5Mohammad Taheri6Maryam Rezazadeh7Maryam Rezazadeh8Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranMolecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranCytoplasmic ribonucleoproteins called stress granules (SGs) are considered as one of the main cellular solutions against stress. Their temporary presence ends with stress relief. Any factor such as chronic stress or mutations in the structure of the components of SGs that lead to their permanent presence can affect their interactions with pathological aggregations and increase the degenerative effects. SGs involved in RNA mechanisms are important factors in the pathophysiology of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal degeneration (FTD), and Alzheimer's diseases (AD). Although many studies have been performed in the field of SGs and neurodegenerative disorders, so far, no systematic studies have been executed in this field. The purpose of this study is to provide a comprehensive perspective of all studies about the role of SGs in the pathogenesis of neurodegenerative disorders with a focus on the protein ingredients of these granules. This scoping review is based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted until December 2020. Publications were screened independently by two reviewers and quantitative and qualitative analysis was performed on the extracted data. Bioinformatics analysis was used to plot the network and predict interprotein interactions. In addition, GO analysis was performed. A total of 48 articles were identified that comply the inclusion criteria. Most studies on neurodegenerative diseases have been conducted on ALS, AD, and FTD using human post mortem tissues. Human derived cell line studies have been used only in ALS. A total 29 genes of protein components of SGs have been studied, the most important of which are TDP-43, TIA-1, PABP-1. Bioinformatics studies have predicted 15 proteins to interact with the protein components of SGs, which may be the constituents of SGs. Understanding the interactions between SGs and pathological aggregations in neurodegenerative diseases can provide new targets for treatment of these disorders.https://www.frontiersin.org/articles/10.3389/fnagi.2021.650740/fullstress granulespathological aggregationsneurodegenerative disordersamyotrophic lateral sclerosisAlzheimer'sTDP-43 |
| spellingShingle | Mohammad Reza Asadi Mohammad Reza Asadi Marziyeh Sadat Moslehian Hani Sabaie Abbas Jalaiei Soudeh Ghafouri-Fard Mohammad Taheri Maryam Rezazadeh Maryam Rezazadeh Stress Granules and Neurodegenerative Disorders: A Scoping Review Frontiers in Aging Neuroscience stress granules pathological aggregations neurodegenerative disorders amyotrophic lateral sclerosis Alzheimer's TDP-43 |
| title | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
| title_full | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
| title_fullStr | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
| title_full_unstemmed | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
| title_short | Stress Granules and Neurodegenerative Disorders: A Scoping Review |
| title_sort | stress granules and neurodegenerative disorders a scoping review |
| topic | stress granules pathological aggregations neurodegenerative disorders amyotrophic lateral sclerosis Alzheimer's TDP-43 |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.650740/full |
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