Electroencephalographic Microstates During Sleep and Wake in Schizophrenia
Background: Aberrant functional connectivity is a hallmark of schizophrenia. The precise nature and mechanism of dysconnectivity in schizophrenia remains unclear, but evidence suggests that dysconnectivity is different in wake versus sleep. Microstate analysis uses electroencephalography (EEG) to in...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
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Elsevier
2024-11-01
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| Sarja: | Biological Psychiatry Global Open Science |
| Aiheet: | |
| Linkit: | http://www.sciencedirect.com/science/article/pii/S2667174324000843 |
| _version_ | 1827125257179234304 |
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| author | Michael Murphy Chenguang Jiang Lei A. Wang Nataliia Kozhemiako Yining Wang Jun Wang Jen Q. Pan Shaun M. Purcell Jun Wang Chenguang Jiang Guanchen Gai Kai Zou Zhe Wang Xiaoman Yu Guoqiang Wang Shuping Tan Michael Murphy Mei Hua Hall Wei Zhu Zhenhe Zhou Lu Shen Shenying Qin Hailiang Huang Nataliia Kozhemiako Lei A. Wang Yining Wang Lin Zhou Shen Li Jun Wang Robert Law Minitrios Mylonas Michael Murphy Robert Stickgold Dara Manoach Mei-Hua Hall Jen Q. Pan Shaun M. Purcell Zhenglin Guo Sinead Chapman Hailiang Huang Jun Wang Chenaugnag Jiang Zhenhe Zhou Jen Q. Pan Mei Hua Hall Hailiang Huang Dara Manoach Jen Q. Pan Shaun M. Purcell Zhenhe Zhou |
| author_facet | Michael Murphy Chenguang Jiang Lei A. Wang Nataliia Kozhemiako Yining Wang Jun Wang Jen Q. Pan Shaun M. Purcell Jun Wang Chenguang Jiang Guanchen Gai Kai Zou Zhe Wang Xiaoman Yu Guoqiang Wang Shuping Tan Michael Murphy Mei Hua Hall Wei Zhu Zhenhe Zhou Lu Shen Shenying Qin Hailiang Huang Nataliia Kozhemiako Lei A. Wang Yining Wang Lin Zhou Shen Li Jun Wang Robert Law Minitrios Mylonas Michael Murphy Robert Stickgold Dara Manoach Mei-Hua Hall Jen Q. Pan Shaun M. Purcell Zhenglin Guo Sinead Chapman Hailiang Huang Jun Wang Chenaugnag Jiang Zhenhe Zhou Jen Q. Pan Mei Hua Hall Hailiang Huang Dara Manoach Jen Q. Pan Shaun M. Purcell Zhenhe Zhou |
| author_sort | Michael Murphy |
| collection | DOAJ |
| description | Background: Aberrant functional connectivity is a hallmark of schizophrenia. The precise nature and mechanism of dysconnectivity in schizophrenia remains unclear, but evidence suggests that dysconnectivity is different in wake versus sleep. Microstate analysis uses electroencephalography (EEG) to investigate large-scale patterns of coordinated brain activity by clustering EEG data into a small set of recurring spatial patterns, or microstates. We hypothesized that this technique would allow us to probe connectivity between brain networks at a fine temporal resolution and uncover previously unknown sleep-specific dysconnectivity. Methods: We studied microstates during sleep in patients with schizophrenia by analyzing high-density EEG sleep data from 114 patients with schizophrenia and 79 control participants. We used a polarity-insensitive k-means analysis to extract a set of 6 microstate topographies. Results: These 6 states included 4 widely reported canonical microstates. In patients and control participants, falling asleep was characterized by a shift from microstates A, B, and C to microstates D, E, and F. Microstate F was decreased in patients during wake, and microstate E was decreased in patients during sleep. The complexity of microstate transitions was greater in patients than control participants during wake, but this reversed during sleep. Conclusions: Our findings reveal behavioral state–dependent patterns of cortical dysconnectivity in schizophrenia. Furthermore, these findings are largely unrelated to previous sleep-related EEG markers of schizophrenia such as decreased sleep spindles. Therefore, these findings are driven by previously undescribed sleep-related pathology in schizophrenia. |
| first_indexed | 2025-03-20T14:53:50Z |
| format | Article |
| id | doaj.art-387b0bd0ece343a88d44c20b230d66e5 |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2025-03-20T14:53:50Z |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-387b0bd0ece343a88d44c20b230d66e52024-09-07T04:49:50ZengElsevierBiological Psychiatry Global Open Science2667-17432024-11-0146100371Electroencephalographic Microstates During Sleep and Wake in SchizophreniaMichael Murphy0Chenguang Jiang1Lei A. Wang2Nataliia Kozhemiako3Yining Wang4Jun Wang5Jen Q. Pan6Shaun M. Purcell7Jun WangChenguang JiangGuanchen GaiKai ZouZhe WangXiaoman YuGuoqiang WangShuping TanMichael MurphyMei Hua HallWei ZhuZhenhe ZhouLu ShenShenying QinHailiang HuangNataliia KozhemiakoLei A. WangYining WangLin ZhouShen LiJun WangRobert LawMinitrios MylonasMichael MurphyRobert StickgoldDara ManoachMei-Hua HallJen Q. PanShaun M. PurcellZhenglin GuoSinead ChapmanHailiang HuangJun WangChenaugnag JiangZhenhe ZhouJen Q. PanMei Hua HallHailiang HuangDara ManoachJen Q. PanShaun M. PurcellZhenhe ZhouDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts; Address correspondence to Michael Murphy, M.D., Ph.D.Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi, Jiangsu, ChinaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MassachusettsDepartment of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MassachusettsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MassachusettsAffiliated Wuxi Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China; Jun Wang, Ph.D.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Jen Q. Pan, Ph.D.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; Shaun M. Purcell, Ph.D.Background: Aberrant functional connectivity is a hallmark of schizophrenia. The precise nature and mechanism of dysconnectivity in schizophrenia remains unclear, but evidence suggests that dysconnectivity is different in wake versus sleep. Microstate analysis uses electroencephalography (EEG) to investigate large-scale patterns of coordinated brain activity by clustering EEG data into a small set of recurring spatial patterns, or microstates. We hypothesized that this technique would allow us to probe connectivity between brain networks at a fine temporal resolution and uncover previously unknown sleep-specific dysconnectivity. Methods: We studied microstates during sleep in patients with schizophrenia by analyzing high-density EEG sleep data from 114 patients with schizophrenia and 79 control participants. We used a polarity-insensitive k-means analysis to extract a set of 6 microstate topographies. Results: These 6 states included 4 widely reported canonical microstates. In patients and control participants, falling asleep was characterized by a shift from microstates A, B, and C to microstates D, E, and F. Microstate F was decreased in patients during wake, and microstate E was decreased in patients during sleep. The complexity of microstate transitions was greater in patients than control participants during wake, but this reversed during sleep. Conclusions: Our findings reveal behavioral state–dependent patterns of cortical dysconnectivity in schizophrenia. Furthermore, these findings are largely unrelated to previous sleep-related EEG markers of schizophrenia such as decreased sleep spindles. Therefore, these findings are driven by previously undescribed sleep-related pathology in schizophrenia.http://www.sciencedirect.com/science/article/pii/S2667174324000843EEGMicrostatesResting-stateSchizophreniaSleepSpindles |
| spellingShingle | Michael Murphy Chenguang Jiang Lei A. Wang Nataliia Kozhemiako Yining Wang Jun Wang Jen Q. Pan Shaun M. Purcell Jun Wang Chenguang Jiang Guanchen Gai Kai Zou Zhe Wang Xiaoman Yu Guoqiang Wang Shuping Tan Michael Murphy Mei Hua Hall Wei Zhu Zhenhe Zhou Lu Shen Shenying Qin Hailiang Huang Nataliia Kozhemiako Lei A. Wang Yining Wang Lin Zhou Shen Li Jun Wang Robert Law Minitrios Mylonas Michael Murphy Robert Stickgold Dara Manoach Mei-Hua Hall Jen Q. Pan Shaun M. Purcell Zhenglin Guo Sinead Chapman Hailiang Huang Jun Wang Chenaugnag Jiang Zhenhe Zhou Jen Q. Pan Mei Hua Hall Hailiang Huang Dara Manoach Jen Q. Pan Shaun M. Purcell Zhenhe Zhou Electroencephalographic Microstates During Sleep and Wake in Schizophrenia Biological Psychiatry Global Open Science EEG Microstates Resting-state Schizophrenia Sleep Spindles |
| title | Electroencephalographic Microstates During Sleep and Wake in Schizophrenia |
| title_full | Electroencephalographic Microstates During Sleep and Wake in Schizophrenia |
| title_fullStr | Electroencephalographic Microstates During Sleep and Wake in Schizophrenia |
| title_full_unstemmed | Electroencephalographic Microstates During Sleep and Wake in Schizophrenia |
| title_short | Electroencephalographic Microstates During Sleep and Wake in Schizophrenia |
| title_sort | electroencephalographic microstates during sleep and wake in schizophrenia |
| topic | EEG Microstates Resting-state Schizophrenia Sleep Spindles |
| url | http://www.sciencedirect.com/science/article/pii/S2667174324000843 |
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