Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

A series of 20 histamine Schiff base was synthesised by reaction of histamine, a well known carbonic anhydrase (CA, E.C 4.2.2.1.) activator pharmacophore, with substituted aldehydes. The obtained histamine Schiff bases were assayed as activators of five selected human (h) CA isozymes, the cytosolic...

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Bibliographic Details
Main Authors:	Suleyman Akocak, Nabih Lolak, Daniela Vullo, Mustafa Durgun, Claudiu T. Supuran
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	Carbonic anhydrase activators histamine Schiff bases isozymes Alzheimer’s disease
Online Access:	http://dx.doi.org/10.1080/14756366.2017.1386660

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