Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations
Apolipoprotein E (apoE) isoforms are genetic determinants of interindividual variations in lipid metabolism. To assess whether apoE is a genetic risk factor for cholesterol gallstone disease (GD), we analyzed apoE variants in populations from Chile and Germany, two countries with very high prevalenc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-07-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520425660 |
| _version_ | 1818731783596802048 |
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| author | Juan G. Mella Ramin Schirin-Sokhan Attilio Rigotti Fernando Pimentel Luis Villarroel Hermann E. Wasmuth Tilman Sauerbruch Flavio Nervi Frank Lammert Juan Francisco Miquel |
| author_facet | Juan G. Mella Ramin Schirin-Sokhan Attilio Rigotti Fernando Pimentel Luis Villarroel Hermann E. Wasmuth Tilman Sauerbruch Flavio Nervi Frank Lammert Juan Francisco Miquel |
| author_sort | Juan G. Mella |
| collection | DOAJ |
| description | Apolipoprotein E (apoE) isoforms are genetic determinants of interindividual variations in lipid metabolism. To assess whether apoE is a genetic risk factor for cholesterol gallstone disease (GD), we analyzed apoE variants in populations from Chile and Germany, two countries with very high prevalence rates of this disease. ApoE genotypes were determined in Chilean gallstone patients (n = 117) and control subjects (n = 122) as well as in German gallstone patients (n = 184) and matched controls (n = 184). In addition, we studied apoE variants in subgroups of Chilean patients with strong differences in their susceptibility to acquire gallstones: 50 elderly subjects without gallstones in spite of well-known risk factors for this disease (gallstone-resistant) and 32 young individuals with gallstones but without risk factors (gallstone-susceptible). Furthermore, correlation analysis of apoE genotypes with cholesterol crystal formation times, biliary cholesterol saturation index (CSI), and gallstone cholesterol contents was performed in 81 cholecystectomized patients. In this study analyzing the largest sample set available, apoE4 genotype was not associated with an increased frequency of GD in either population. Moreover, in the Chilean population after adjusting for risk factors such as gender, age, body mass index, serum lipids, and glucose, the odds ratio for the association of the apoE4 allele and GD was significantly (P < 0.05) <1. Also, genotypes were not correlated with cholesterol crystal formation time, CSI, or gallstone cholesterol content. In contrast to previous smaller studies, apoE polymorphisms were not associated with susceptibility to cholesterol GD in high-risk populations. |
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| format | Article |
| id | doaj.art-387caafd0f8441bba955e61d97d39dab |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T23:23:10Z |
| publishDate | 2007-07-01 |
| publisher | Elsevier |
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| series | Journal of Lipid Research |
| spelling | doaj.art-387caafd0f8441bba955e61d97d39dab2022-12-21T21:28:50ZengElsevierJournal of Lipid Research0022-22752007-07-0148613781385Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populationsJuan G. Mella0Ramin Schirin-Sokhan1Attilio Rigotti2Fernando Pimentel3Luis Villarroel4Hermann E. Wasmuth5Tilman Sauerbruch6Flavio Nervi7Frank Lammert8Juan Francisco Miquel9Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Medicine III, University Hospital Aachen, Aachen University, Aachen, GermanyDepartamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Cirugía Digestiva, Pontificia Universidad Católica de Chile, Santiago, ChileSalud Pública Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Medicine III, University Hospital Aachen, Aachen University, Aachen, GermanyDepartment of Internal Medicine I, University Hospital Bonn, University of Bonn, Bonn, GermanyDepartamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany; Department of Internal Medicine I, University Hospital Bonn, University of Bonn, Bonn, GermanyDepartamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, ChileApolipoprotein E (apoE) isoforms are genetic determinants of interindividual variations in lipid metabolism. To assess whether apoE is a genetic risk factor for cholesterol gallstone disease (GD), we analyzed apoE variants in populations from Chile and Germany, two countries with very high prevalence rates of this disease. ApoE genotypes were determined in Chilean gallstone patients (n = 117) and control subjects (n = 122) as well as in German gallstone patients (n = 184) and matched controls (n = 184). In addition, we studied apoE variants in subgroups of Chilean patients with strong differences in their susceptibility to acquire gallstones: 50 elderly subjects without gallstones in spite of well-known risk factors for this disease (gallstone-resistant) and 32 young individuals with gallstones but without risk factors (gallstone-susceptible). Furthermore, correlation analysis of apoE genotypes with cholesterol crystal formation times, biliary cholesterol saturation index (CSI), and gallstone cholesterol contents was performed in 81 cholecystectomized patients. In this study analyzing the largest sample set available, apoE4 genotype was not associated with an increased frequency of GD in either population. Moreover, in the Chilean population after adjusting for risk factors such as gender, age, body mass index, serum lipids, and glucose, the odds ratio for the association of the apoE4 allele and GD was significantly (P < 0.05) <1. Also, genotypes were not correlated with cholesterol crystal formation time, CSI, or gallstone cholesterol content. In contrast to previous smaller studies, apoE polymorphisms were not associated with susceptibility to cholesterol GD in high-risk populations.http://www.sciencedirect.com/science/article/pii/S0022227520425660gallstone diseasecholesterolgenetic association study |
| spellingShingle | Juan G. Mella Ramin Schirin-Sokhan Attilio Rigotti Fernando Pimentel Luis Villarroel Hermann E. Wasmuth Tilman Sauerbruch Flavio Nervi Frank Lammert Juan Francisco Miquel Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations Journal of Lipid Research gallstone disease cholesterol genetic association study |
| title | Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations |
| title_full | Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations |
| title_fullStr | Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations |
| title_full_unstemmed | Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations |
| title_short | Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations |
| title_sort | genetic evidence that apolipoprotein e4 is not a relevant susceptibility factor for cholelithiasis in two high risk populations |
| topic | gallstone disease cholesterol genetic association study |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520425660 |
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