Autapses enhance bursting and coincidence detection in neocortical pyramidal cells
While autapses are synapses made by a neuron onto itself, its functional significance in pyramidal cells are not clear. Here, the authors show that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection from other inputs.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07317-4 |
| _version_ | 1818992682742054912 |
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| author | Luping Yin Rui Zheng Wei Ke Quansheng He Yi Zhang Junlong Li Bo Wang Zhen Mi Yue-sheng Long Malte J. Rasch Tianfu Li Guoming Luan Yousheng Shu |
| author_facet | Luping Yin Rui Zheng Wei Ke Quansheng He Yi Zhang Junlong Li Bo Wang Zhen Mi Yue-sheng Long Malte J. Rasch Tianfu Li Guoming Luan Yousheng Shu |
| author_sort | Luping Yin |
| collection | DOAJ |
| description | While autapses are synapses made by a neuron onto itself, its functional significance in pyramidal cells are not clear. Here, the authors show that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection from other inputs. |
| first_indexed | 2024-12-20T20:30:03Z |
| format | Article |
| id | doaj.art-387d2ac97fcc4d5db68d5938d05e9905 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:30:03Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-387d2ac97fcc4d5db68d5938d05e99052022-12-21T19:27:22ZengNature PortfolioNature Communications2041-17232018-11-019111210.1038/s41467-018-07317-4Autapses enhance bursting and coincidence detection in neocortical pyramidal cellsLuping Yin0Rui Zheng1Wei Ke2Quansheng He3Yi Zhang4Junlong Li5Bo Wang6Zhen Mi7Yue-sheng Long8Malte J. Rasch9Tianfu Li10Guoming Luan11Yousheng Shu12State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityDepartment of Neurology, Epilepsy Center, Sanbo Brain Hospital, Capital Medical UniversityDepartment of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityWhile autapses are synapses made by a neuron onto itself, its functional significance in pyramidal cells are not clear. Here, the authors show that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection from other inputs.https://doi.org/10.1038/s41467-018-07317-4 |
| spellingShingle | Luping Yin Rui Zheng Wei Ke Quansheng He Yi Zhang Junlong Li Bo Wang Zhen Mi Yue-sheng Long Malte J. Rasch Tianfu Li Guoming Luan Yousheng Shu Autapses enhance bursting and coincidence detection in neocortical pyramidal cells Nature Communications |
| title | Autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| title_full | Autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| title_fullStr | Autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| title_full_unstemmed | Autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| title_short | Autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| title_sort | autapses enhance bursting and coincidence detection in neocortical pyramidal cells |
| url | https://doi.org/10.1038/s41467-018-07317-4 |
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