Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications
BackgroundHerein we investigate the difference between Kawasaki disease (KD) with and without a recent history of SARS-CoV-2 infection.MethodsWe compared the clinical characteristics of patients with KD during the SARS-CoV-2 pandemic in a single children's hospital in Korea. Fifty-two patients...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1036306/full |
| _version_ | 1811307422569988096 |
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| author | Da Eun Roh Young Tae Lim Jung Eun Kwon Jung Eun Kwon Yeo Hyang Kim Yeo Hyang Kim |
| author_facet | Da Eun Roh Young Tae Lim Jung Eun Kwon Jung Eun Kwon Yeo Hyang Kim Yeo Hyang Kim |
| author_sort | Da Eun Roh |
| collection | DOAJ |
| description | BackgroundHerein we investigate the difference between Kawasaki disease (KD) with and without a recent history of SARS-CoV-2 infection.MethodsWe compared the clinical characteristics of patients with KD during the SARS-CoV-2 pandemic in a single children's hospital in Korea. Fifty-two patients were enrolled and divided into group 1 (with a history of COVID-19, n = 26) and group 2 (without a history of COVID-19, n = 26) according to whether or not they contracted COVID-19 within the 8 weeks before hospitalization. Data, including clinical features and laboratory results, were analyzed and compared between groups.ResultsThe median age of patients was significantly higher in group 1 than in group 2 (53 months [IQR, 24–81] vs. 15 months [IQR, 6–33], p = 0.001). The incidence of cervical lymphadenopathy was significantly higher (p = 0.017), while that of BCGitis was significantly lower in group 1 (p = 0.023), and patients had a significantly longer hospital stay (5 days [IQR, 3–8] vs. 3 days [IQR, 3–4], p = 0.008). In group 1, platelet count was significantly lower (p = 0.006), and hemoglobin and ferritin levels were significantly higher (p = 0.013 and p = 0.001, respectively) on the first admission day. Following treatment with intravenous immunoglobulin (IVIG), the platelet count was significantly lower (p = 0.015), and the percentage of neutrophils and neutrophil-to-lymphocyte ratio were significantly higher in group 1 (p = 0.037 and p = 0.012). Although there was no statistical difference, patients requiring infliximab treatment due to prolonged fever was only in group 1. The incidence of cardiovascular complications did not differ between the groups.ConclusionsPost-COVID KD showed a stronger inflammatory response than KD-alone, with no differences in cardiac complications. |
| first_indexed | 2024-04-13T09:04:06Z |
| format | Article |
| id | doaj.art-387d72da98114e77ae795c6b19567d9c |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T09:04:06Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-387d72da98114e77ae795c6b19567d9c2022-12-22T02:53:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-11-011010.3389/fped.2022.10363061036306Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complicationsDa Eun Roh0Young Tae Lim1Jung Eun Kwon2Jung Eun Kwon3Yeo Hyang Kim4Yeo Hyang Kim5Department of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, South KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South KoreaDivision of Pediatric Cardiology, Kyungpook National University Children's Hospital, Daegu, South KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South KoreaDivision of Pediatric Cardiology, Kyungpook National University Children's Hospital, Daegu, South KoreaBackgroundHerein we investigate the difference between Kawasaki disease (KD) with and without a recent history of SARS-CoV-2 infection.MethodsWe compared the clinical characteristics of patients with KD during the SARS-CoV-2 pandemic in a single children's hospital in Korea. Fifty-two patients were enrolled and divided into group 1 (with a history of COVID-19, n = 26) and group 2 (without a history of COVID-19, n = 26) according to whether or not they contracted COVID-19 within the 8 weeks before hospitalization. Data, including clinical features and laboratory results, were analyzed and compared between groups.ResultsThe median age of patients was significantly higher in group 1 than in group 2 (53 months [IQR, 24–81] vs. 15 months [IQR, 6–33], p = 0.001). The incidence of cervical lymphadenopathy was significantly higher (p = 0.017), while that of BCGitis was significantly lower in group 1 (p = 0.023), and patients had a significantly longer hospital stay (5 days [IQR, 3–8] vs. 3 days [IQR, 3–4], p = 0.008). In group 1, platelet count was significantly lower (p = 0.006), and hemoglobin and ferritin levels were significantly higher (p = 0.013 and p = 0.001, respectively) on the first admission day. Following treatment with intravenous immunoglobulin (IVIG), the platelet count was significantly lower (p = 0.015), and the percentage of neutrophils and neutrophil-to-lymphocyte ratio were significantly higher in group 1 (p = 0.037 and p = 0.012). Although there was no statistical difference, patients requiring infliximab treatment due to prolonged fever was only in group 1. The incidence of cardiovascular complications did not differ between the groups.ConclusionsPost-COVID KD showed a stronger inflammatory response than KD-alone, with no differences in cardiac complications.https://www.frontiersin.org/articles/10.3389/fped.2022.1036306/fullSARS-CoV-2COVID-19mucocutaneous lymph node syndromepediatric multisystem inflammatory diseaseCOVID-19 relatedmacrophage activation syndrome |
| spellingShingle | Da Eun Roh Young Tae Lim Jung Eun Kwon Jung Eun Kwon Yeo Hyang Kim Yeo Hyang Kim Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications Frontiers in Pediatrics SARS-CoV-2 COVID-19 mucocutaneous lymph node syndrome pediatric multisystem inflammatory disease COVID-19 related macrophage activation syndrome |
| title | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications |
| title_full | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications |
| title_fullStr | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications |
| title_full_unstemmed | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications |
| title_short | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications |
| title_sort | kawasaki disease following sars cov 2 infection stronger inflammation with no increase in cardiac complications |
| topic | SARS-CoV-2 COVID-19 mucocutaneous lymph node syndrome pediatric multisystem inflammatory disease COVID-19 related macrophage activation syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1036306/full |
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