Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome
Abstract Background In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0438-y |
| _version_ | 1819236274595168256 |
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| author | Kazuichi Maruyama Yuko Maruyama Sunao Sugita Kazuhiko Mori Yu Yokoyama Shiho Sanuki-Kunimatsu Hiroko Nakagawa Shigeru Kinoshita Manabu Mochizuki Toru Nakazawa |
| author_facet | Kazuichi Maruyama Yuko Maruyama Sunao Sugita Kazuhiko Mori Yu Yokoyama Shiho Sanuki-Kunimatsu Hiroko Nakagawa Shigeru Kinoshita Manabu Mochizuki Toru Nakazawa |
| author_sort | Kazuichi Maruyama |
| collection | DOAJ |
| description | Abstract Background In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner–Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. Methods This study was a retrospective case-series analysis of the clinical charts of 33 patients diagnosed with PSS, who underwent surgery to control IOP or received medication only. Various clinical factors were compared between the surgical and medication groups. Results The surgical group had a higher corneal endothelial cell (CEC) density loss (p < 0.05), higher maximum IOP (p < 0.01), greater visual field loss (p < 0.01) and higher positive number for cytomegalovirus (CMV) (p < 0.001) than the non-surgical group. Eighteen of the 33 patients had a high CEC reduction ratio. Of these 18, 16 required glaucoma surgery. Conclusions PSS patients with a higher CEC reduction ratio, higher maximum IOP, greater visual field loss and higher positive number for CMV in the aqueous humor tended to be more likely to require progressive treatment, such as glaucoma surgery. |
| first_indexed | 2024-12-23T13:01:50Z |
| format | Article |
| id | doaj.art-387d7ac2984b401baf320b8d3b44ce05 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-23T13:01:50Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-387d7ac2984b401baf320b8d3b44ce052022-12-21T17:46:00ZengBMCBMC Ophthalmology1471-24152017-04-011711710.1186/s12886-017-0438-yCharacteristics of cases needing advanced treatment for intractable Posner–Schlossman syndromeKazuichi Maruyama0Yuko Maruyama1Sunao Sugita2Kazuhiko Mori3Yu Yokoyama4Shiho Sanuki-Kunimatsu5Hiroko Nakagawa6Shigeru Kinoshita7Manabu Mochizuki8Toru Nakazawa9Department of Ophthalmology and Visual Science, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Kyoto Prefectural University of MedicineRIKEN Center for Development BiologyDepartment of Ophthalmology, Kyoto Prefectural University of MedicineDepartment of Ophthalmology and Visual Science, Tohoku University Graduate School of MedicineDepartment of Ophthalmology and Visual Science, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Kyoto Prefectural University of MedicineDepartment of Ophthalmology, Kyoto Prefectural University of MedicineDepartment of Ophthalmology, Tokyo Medical and Dental University, School of MedicineDepartment of Ophthalmology and Visual Science, Tohoku University Graduate School of MedicineAbstract Background In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner–Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. Methods This study was a retrospective case-series analysis of the clinical charts of 33 patients diagnosed with PSS, who underwent surgery to control IOP or received medication only. Various clinical factors were compared between the surgical and medication groups. Results The surgical group had a higher corneal endothelial cell (CEC) density loss (p < 0.05), higher maximum IOP (p < 0.01), greater visual field loss (p < 0.01) and higher positive number for cytomegalovirus (CMV) (p < 0.001) than the non-surgical group. Eighteen of the 33 patients had a high CEC reduction ratio. Of these 18, 16 required glaucoma surgery. Conclusions PSS patients with a higher CEC reduction ratio, higher maximum IOP, greater visual field loss and higher positive number for CMV in the aqueous humor tended to be more likely to require progressive treatment, such as glaucoma surgery.http://link.springer.com/article/10.1186/s12886-017-0438-yPosner–Schlossman syndrome (PSS)Corneal endothelial cell (CEC) densityIntraocular pressure (IOP)Glaucoma surgeryPolymerase chain reaction (PCR) |
| spellingShingle | Kazuichi Maruyama Yuko Maruyama Sunao Sugita Kazuhiko Mori Yu Yokoyama Shiho Sanuki-Kunimatsu Hiroko Nakagawa Shigeru Kinoshita Manabu Mochizuki Toru Nakazawa Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome BMC Ophthalmology Posner–Schlossman syndrome (PSS) Corneal endothelial cell (CEC) density Intraocular pressure (IOP) Glaucoma surgery Polymerase chain reaction (PCR) |
| title | Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome |
| title_full | Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome |
| title_fullStr | Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome |
| title_full_unstemmed | Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome |
| title_short | Characteristics of cases needing advanced treatment for intractable Posner–Schlossman syndrome |
| title_sort | characteristics of cases needing advanced treatment for intractable posner schlossman syndrome |
| topic | Posner–Schlossman syndrome (PSS) Corneal endothelial cell (CEC) density Intraocular pressure (IOP) Glaucoma surgery Polymerase chain reaction (PCR) |
| url | http://link.springer.com/article/10.1186/s12886-017-0438-y |
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