The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus
Background. The literature does not provide enough information about the role of vitamin D in the genesis of diabetic retinopathy. The active metabolite of vitamin D, calcitriol, is a potent retinal neovascularization inhibitor in an experimental model of ischemic retinopathy. There is very few evid...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2022-12-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1221 |
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| author | V.I. Pankiv T.Yu. Yuzvenko N.V. Pashkovska I.V. Pankiv |
| author_facet | V.I. Pankiv T.Yu. Yuzvenko N.V. Pashkovska I.V. Pankiv |
| author_sort | V.I. Pankiv |
| collection | DOAJ |
| description | Background. The literature does not provide enough information about the role of vitamin D in the genesis of diabetic retinopathy. The active metabolite of vitamin D, calcitriol, is a potent retinal neovascularization inhibitor in an experimental model of ischemic retinopathy. There is very few evidence on the possible relationship between the content of vitamin D and the incidence of diabetic retinopathy in type 2 diabetes mellitus (DM) patients in the European population, including Ukraine. The purpose of the study is to establish the association between vitamin D status and the incidence of diabetic retinopathy in patients with type 2 DM. Material and methods. In the case-control observational study, two groups of patients with type 2 DM were examined: 55 with diabetic retinopathy (cases) and 35 without retinopathy (controls). All of them had normal kidney function (glomerular filtration rate > 60 ml/min, without microalbuminuria) in the absence of cardiovascular complications. Patients did not receive calcium and/or vitamin D preparations. Results. The study confirms the relationship between 25(OH)D content and the presence of diabetic retinopathy in patients with type 2 DM. Patients with retinopathy had a significantly lower concentration of 25(OH)D — 14.6 ± 2.9 ng/ml versus 23.9 ± 3.1 ng/ml in patients without retinopathy, p < 0.05. The multivariate analyses demonstrated a significant association of diabetic retinopathy and 25(OH)D. Conclusions. The results indicate the potential role of vitamin D in the pathogenesis of diabetic retinopathy. Further experimental and prospective studies are needed to determine the role of vitamin D status in the development of diabetic retinopathy and other diabetic microvascular complications. |
| first_indexed | 2024-03-13T07:18:55Z |
| format | Article |
| id | doaj.art-387fb86f14c146afb5051822837c8348 |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-03-13T07:18:55Z |
| publishDate | 2022-12-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-387fb86f14c146afb5051822837c83482023-06-04T19:42:12ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272022-12-0118843243510.22141/2224-0721.18.8.2022.12211219The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitusV.I. Pankiv0https://orcid.org/0000-0002-9205-9530T.Yu. Yuzvenko1https://orcid.org/0000-0003-4229-2075N.V. Pashkovska2https://orcid.org/0000-0002-9896-1744I.V. Pankiv3https://orcid.org/0000-0001-5576-636XUkrainian Research and Practical Centre of Endocrine Surgery, Transplantations of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, UkraineUkrainian Research and Practical Centre of Endocrine Surgery, Transplantations of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, UkraineBukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineBackground. The literature does not provide enough information about the role of vitamin D in the genesis of diabetic retinopathy. The active metabolite of vitamin D, calcitriol, is a potent retinal neovascularization inhibitor in an experimental model of ischemic retinopathy. There is very few evidence on the possible relationship between the content of vitamin D and the incidence of diabetic retinopathy in type 2 diabetes mellitus (DM) patients in the European population, including Ukraine. The purpose of the study is to establish the association between vitamin D status and the incidence of diabetic retinopathy in patients with type 2 DM. Material and methods. In the case-control observational study, two groups of patients with type 2 DM were examined: 55 with diabetic retinopathy (cases) and 35 without retinopathy (controls). All of them had normal kidney function (glomerular filtration rate > 60 ml/min, without microalbuminuria) in the absence of cardiovascular complications. Patients did not receive calcium and/or vitamin D preparations. Results. The study confirms the relationship between 25(OH)D content and the presence of diabetic retinopathy in patients with type 2 DM. Patients with retinopathy had a significantly lower concentration of 25(OH)D — 14.6 ± 2.9 ng/ml versus 23.9 ± 3.1 ng/ml in patients without retinopathy, p < 0.05. The multivariate analyses demonstrated a significant association of diabetic retinopathy and 25(OH)D. Conclusions. The results indicate the potential role of vitamin D in the pathogenesis of diabetic retinopathy. Further experimental and prospective studies are needed to determine the role of vitamin D status in the development of diabetic retinopathy and other diabetic microvascular complications.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1221type 2 diabetes mellitusdiabetic retinopathyvitamin d |
| spellingShingle | V.I. Pankiv T.Yu. Yuzvenko N.V. Pashkovska I.V. Pankiv The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus Mìžnarodnij Endokrinologìčnij Žurnal type 2 diabetes mellitus diabetic retinopathy vitamin d |
| title | The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| title_full | The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| title_fullStr | The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| title_full_unstemmed | The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| title_short | The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| title_sort | relationship between serum vitamin d concentrations and development of diabetic retinopathy in type 2 diabetes mellitus |
| topic | type 2 diabetes mellitus diabetic retinopathy vitamin d |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1221 |
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