Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients
Abstract Background α‐1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum...
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.686 |
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| author | Ning Yang Long‐kai Li Hui He Xia‐nan Guo Xue‐feng Yuan Zhi‐tong Li Wei‐dong Wang Biao‐jie Qin Xiang‐ning Du Xu Zhang Shu‐ni Chen Hong‐li Lin |
| author_facet | Ning Yang Long‐kai Li Hui He Xia‐nan Guo Xue‐feng Yuan Zhi‐tong Li Wei‐dong Wang Biao‐jie Qin Xiang‐ning Du Xu Zhang Shu‐ni Chen Hong‐li Lin |
| author_sort | Ning Yang |
| collection | DOAJ |
| description | Abstract Background α‐1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum FUT8 activity with renal tubulointerstitial injury in IgAN patients. Methods Serum FUT8 activity was measured in 135 IgAN patients and 68 healthy controls from January 2016 to December 2018. The relationships of serum FUT8 activity with clinical and pathological features were analyzed. Results Relative to healthy controls, IgAN patients had significantly higher serum FUT8 activity and upregulation of renal FUT8 protein (p < .05). Among IgAN patients, there was a positive correlation of serum FUT8 activity with renal FUT8 protein expression (p < .05). Multivariable logistic regression analyses showed that serum FUT8 activity was significantly associated with serum creatinine and eGFR (p < .05). Based on a cut‐off value determined from ROC curve analysis, we divided IgAN patients into a low serum FUT8 activity group (≤12.2 pmol/h/mL, n = 40) and a high serum FUT8 activity group (>12.2 pmol/h/ml, n = 95). The high serum FUT8 activity group had a higher Oxford T score, increased inflammatory cell infiltration, more severe fibrosis and poor renal function (p < .05). Conclusion Serum FUT8 activity was positive association with renal tubulointerstitial injury in IgAN patients. |
| first_indexed | 2024-04-11T04:18:17Z |
| format | Article |
| id | doaj.art-3882a85ddc704a289c5223184957c340 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-11T04:18:17Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-3882a85ddc704a289c5223184957c3402022-12-31T08:06:09ZengWileyImmunity, Inflammation and Disease2050-45272022-09-01109n/an/a10.1002/iid3.686Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patientsNing Yang0Long‐kai Li1Hui He2Xia‐nan Guo3Xue‐feng Yuan4Zhi‐tong Li5Wei‐dong Wang6Biao‐jie Qin7Xiang‐ning Du8Xu Zhang9Shu‐ni Chen10Hong‐li Lin11Graduate School of Dalian Medical University Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaGraduate School of Dalian Medical University Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaGraduate School of Dalian Medical University Dalian Medical University Dalian ChinaGraduate School of Dalian Medical University Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology The First Affiliated Hospital of Dalian Medical University Dalian ChinaAbstract Background α‐1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum FUT8 activity with renal tubulointerstitial injury in IgAN patients. Methods Serum FUT8 activity was measured in 135 IgAN patients and 68 healthy controls from January 2016 to December 2018. The relationships of serum FUT8 activity with clinical and pathological features were analyzed. Results Relative to healthy controls, IgAN patients had significantly higher serum FUT8 activity and upregulation of renal FUT8 protein (p < .05). Among IgAN patients, there was a positive correlation of serum FUT8 activity with renal FUT8 protein expression (p < .05). Multivariable logistic regression analyses showed that serum FUT8 activity was significantly associated with serum creatinine and eGFR (p < .05). Based on a cut‐off value determined from ROC curve analysis, we divided IgAN patients into a low serum FUT8 activity group (≤12.2 pmol/h/mL, n = 40) and a high serum FUT8 activity group (>12.2 pmol/h/ml, n = 95). The high serum FUT8 activity group had a higher Oxford T score, increased inflammatory cell infiltration, more severe fibrosis and poor renal function (p < .05). Conclusion Serum FUT8 activity was positive association with renal tubulointerstitial injury in IgAN patients.https://doi.org/10.1002/iid3.686IgA nephropathyserum FUT8 activitytubulointerstitial injury |
| spellingShingle | Ning Yang Long‐kai Li Hui He Xia‐nan Guo Xue‐feng Yuan Zhi‐tong Li Wei‐dong Wang Biao‐jie Qin Xiang‐ning Du Xu Zhang Shu‐ni Chen Hong‐li Lin Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients Immunity, Inflammation and Disease IgA nephropathy serum FUT8 activity tubulointerstitial injury |
| title | Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients |
| title_full | Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients |
| title_fullStr | Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients |
| title_full_unstemmed | Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients |
| title_short | Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients |
| title_sort | positive association of serum fut8 activity with renal tubulointerstitial injury in iga nephropathy patients |
| topic | IgA nephropathy serum FUT8 activity tubulointerstitial injury |
| url | https://doi.org/10.1002/iid3.686 |
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