The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility
Toxoplasmosis is a worldwide zoonosis that generally produces an asymptomatic infection. In some cases, however, toxoplasmosis infection can lead to ocular damage. The immune system has a crucial role in both the course of the infection and in the evolution of toxoplasmosis disease. In particular, I...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300009 |
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| author | Maíra Cavalcanti de Albuquerque Ana Luisa Quintella do Couto Aleixo Eliezer Israel Benchimol Ana Cristina Câmara S Leandro Leandro Batista das Neves Regiane Trigueiro Vicente Maria da Glória Bonecini-Almeida Maria Regina Reis Amendoeira |
| author_facet | Maíra Cavalcanti de Albuquerque Ana Luisa Quintella do Couto Aleixo Eliezer Israel Benchimol Ana Cristina Câmara S Leandro Leandro Batista das Neves Regiane Trigueiro Vicente Maria da Glória Bonecini-Almeida Maria Regina Reis Amendoeira |
| author_sort | Maíra Cavalcanti de Albuquerque |
| collection | DOAJ |
| description | Toxoplasmosis is a worldwide zoonosis that generally produces an asymptomatic infection. In some cases, however, toxoplasmosis infection can lead to ocular damage. The immune system has a crucial role in both the course of the infection and in the evolution of toxoplasmosis disease. In particular, IFN-³ plays an important role in resistance to toxoplasmosis. Polymorphisms in genes encoding cytokines have been shown to have an association with susceptibility to parasitic diseases. The aim of this work was to analyse the occurrence of polymorphisms in the gene encoding IFN-³ (+874T/A) among Toxoplasma gondii seropositive individuals, including those with ocular lesions caused by the parasite, from a rural population of Santa Rita de Cássia, Barra Mansa, state of Rio de Janeiro, Brazil. Further, we verified which of these polymorphisms could be related to susceptibility to the development of ocular toxoplasmosis. This study included 34 individuals with ocular toxoplasmosis (ocular group) and 134 without ocular lesions (control group). The differences between A and T allele distributions were not statistically significant between the two groups. However, we observed that a higher frequency of individuals from the ocular group possessed the A/A genotype, when compared with the control group, suggesting that homozygocity for the A allele could enhance susceptibility to ocular toxoplasmosis in T. gondii infection. |
| first_indexed | 2024-03-12T07:25:03Z |
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| id | doaj.art-38830f4286454d62ad930bea7c0d2a26 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:25:03Z |
| publishDate | 2009-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-38830f4286454d62ad930bea7c0d2a262023-09-02T22:10:59ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-05-01104345145510.1590/S0074-02762009000300009The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibilityMaíra Cavalcanti de AlbuquerqueAna Luisa Quintella do Couto AleixoEliezer Israel BenchimolAna Cristina Câmara S LeandroLeandro Batista das NevesRegiane Trigueiro VicenteMaria da Glória Bonecini-AlmeidaMaria Regina Reis AmendoeiraToxoplasmosis is a worldwide zoonosis that generally produces an asymptomatic infection. In some cases, however, toxoplasmosis infection can lead to ocular damage. The immune system has a crucial role in both the course of the infection and in the evolution of toxoplasmosis disease. In particular, IFN-³ plays an important role in resistance to toxoplasmosis. Polymorphisms in genes encoding cytokines have been shown to have an association with susceptibility to parasitic diseases. The aim of this work was to analyse the occurrence of polymorphisms in the gene encoding IFN-³ (+874T/A) among Toxoplasma gondii seropositive individuals, including those with ocular lesions caused by the parasite, from a rural population of Santa Rita de Cássia, Barra Mansa, state of Rio de Janeiro, Brazil. Further, we verified which of these polymorphisms could be related to susceptibility to the development of ocular toxoplasmosis. This study included 34 individuals with ocular toxoplasmosis (ocular group) and 134 without ocular lesions (control group). The differences between A and T allele distributions were not statistically significant between the two groups. However, we observed that a higher frequency of individuals from the ocular group possessed the A/A genotype, when compared with the control group, suggesting that homozygocity for the A allele could enhance susceptibility to ocular toxoplasmosis in T. gondii infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300009toxoplasmosisinterferon-gammachorioretinitissingle nucleotide polymorphism |
| spellingShingle | Maíra Cavalcanti de Albuquerque Ana Luisa Quintella do Couto Aleixo Eliezer Israel Benchimol Ana Cristina Câmara S Leandro Leandro Batista das Neves Regiane Trigueiro Vicente Maria da Glória Bonecini-Almeida Maria Regina Reis Amendoeira The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility Memorias do Instituto Oswaldo Cruz toxoplasmosis interferon-gamma chorioretinitis single nucleotide polymorphism |
| title | The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| title_full | The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| title_fullStr | The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| title_full_unstemmed | The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| title_short | The IFN-³+874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| title_sort | ifn ³ 874t a gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility |
| topic | toxoplasmosis interferon-gamma chorioretinitis single nucleotide polymorphism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300009 |
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