Molecular function of Krüppel-like factor 7 in biology
Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports a...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2023-05-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2023061 |
| _version_ | 1797635800935956480 |
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| author | Mao Yi Chen Yuechan Zhang Zhiwei |
| author_facet | Mao Yi Chen Yuechan Zhang Zhiwei |
| author_sort | Mao Yi |
| collection | DOAJ |
| description | Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports are demonstrating that KLF7 plays an important role in development and diseases. Genetic studies have shown that the DNA polymorphisms of KLF7 are associated with obesity, type 2 diabetes mellitus (T2DM), lachrymal/salivary gland lesions, and mental development in some populations of humans, and the DNA methylation of KLF7 is associated with the development of diffuse gastric cancer. In addition, biological function studies have shown that KLF7 regulates the development of the nervous system, adipose tissue, muscle tissue and corneal epithelium as well as the preservation of pluripotent stem cells. Additionally, disease-related studies have shown that KLF7 is involved in the development or progression of T2DM, hematologic diseases, lung cancer, gastric cancer, squamous cell carcinoma of the head and neck, pancreatic ductal adenocarcinoma, glioma, advanced high-grade serous ovarian cancer and osteosarcoma. This review provides research progress on the genetic association, molecular properties and biological function of KLF7, and it may shed light on the understanding of the molecular function of KLF7 in biology and the molecular mechanisms of some diseases. |
| first_indexed | 2024-03-11T12:26:30Z |
| format | Article |
| id | doaj.art-38836d76084c490e80f622375df47deb |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:26:30Z |
| publishDate | 2023-05-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-38836d76084c490e80f622375df47deb2023-11-06T08:47:29ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452023-05-015571372510.3724/abbs.202306120d259ccMolecular function of Krüppel-like factor 7 in biologyMao Yi0Chen Yuechan1Zhang Zhiwei2["Department of Histology and Embryology/Key Laboratory of Xinjiang Endemic and Ethnic Diseases of Ministry of Education, Shihezi University School of Medicine, Shihezi 832000, China"]["Department of Reproductive Medicine, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi 832000, China"]["Department of Histology and Embryology/Key Laboratory of Xinjiang Endemic and Ethnic Diseases of Ministry of Education, Shihezi University School of Medicine, Shihezi 832000, China"]Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports are demonstrating that KLF7 plays an important role in development and diseases. Genetic studies have shown that the DNA polymorphisms of KLF7 are associated with obesity, type 2 diabetes mellitus (T2DM), lachrymal/salivary gland lesions, and mental development in some populations of humans, and the DNA methylation of KLF7 is associated with the development of diffuse gastric cancer. In addition, biological function studies have shown that KLF7 regulates the development of the nervous system, adipose tissue, muscle tissue and corneal epithelium as well as the preservation of pluripotent stem cells. Additionally, disease-related studies have shown that KLF7 is involved in the development or progression of T2DM, hematologic diseases, lung cancer, gastric cancer, squamous cell carcinoma of the head and neck, pancreatic ductal adenocarcinoma, glioma, advanced high-grade serous ovarian cancer and osteosarcoma. This review provides research progress on the genetic association, molecular properties and biological function of KLF7, and it may shed light on the understanding of the molecular function of KLF7 in biology and the molecular mechanisms of some diseases. https://www.sciengine.com/doi/10.3724/abbs.2023061Krüppel-like factor 7 ( <italic>KLF7</italic>)genetic associationmolecular propertiesbiological function |
| spellingShingle | Mao Yi Chen Yuechan Zhang Zhiwei Molecular function of Krüppel-like factor 7 in biology Acta Biochimica et Biophysica Sinica Krüppel-like factor 7 ( <italic>KLF7</italic>) genetic association molecular properties biological function |
| title | Molecular function of Krüppel-like factor 7 in biology |
| title_full | Molecular function of Krüppel-like factor 7 in biology |
| title_fullStr | Molecular function of Krüppel-like factor 7 in biology |
| title_full_unstemmed | Molecular function of Krüppel-like factor 7 in biology |
| title_short | Molecular function of Krüppel-like factor 7 in biology |
| title_sort | molecular function of kruppel like factor 7 in biology |
| topic | Krüppel-like factor 7 ( <italic>KLF7</italic>) genetic association molecular properties biological function |
| url | https://www.sciengine.com/doi/10.3724/abbs.2023061 |
| work_keys_str_mv | AT maoyi molecularfunctionofkruppellikefactor7inbiology AT chenyuechan molecularfunctionofkruppellikefactor7inbiology AT zhangzhiwei molecularfunctionofkruppellikefactor7inbiology |