Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea
ABSTRACTFollowing the global emergence of the SARS-CoV-2 Alpha variant of concern (VOC) in 2020, the Delta variant triggered another wave in 2021. The AY.69 lineage, a Delta VOC, was particularly prevalent in Republic of Korea (South Korea) from May 2021 to January 2022, despite the synchronized imp...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2228934 |
| _version_ | 1797257042445991936 |
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| author | Sangyi Lee Dong-Wook Lee Jeong-Min Kim Da-Won Kim Ji-Yun Kim Jeong-Ah Kim Il-Hwan Kim Jee Eun Rhee Kyung-duk Min Sung-il Cho Eun-Jin Kim Jung-Hoon Kwon |
| author_facet | Sangyi Lee Dong-Wook Lee Jeong-Min Kim Da-Won Kim Ji-Yun Kim Jeong-Ah Kim Il-Hwan Kim Jee Eun Rhee Kyung-duk Min Sung-il Cho Eun-Jin Kim Jung-Hoon Kwon |
| author_sort | Sangyi Lee |
| collection | DOAJ |
| description | ABSTRACTFollowing the global emergence of the SARS-CoV-2 Alpha variant of concern (VOC) in 2020, the Delta variant triggered another wave in 2021. The AY.69 lineage, a Delta VOC, was particularly prevalent in Republic of Korea (South Korea) from May 2021 to January 2022, despite the synchronized implementation of vaccination programmes and non-pharmaceutical interventions (NPIs) such as social distancing. In this study, we used phylogeographic analysis combined with a generalized linear model (GLM) to examine the impact of human movement and vaccination on viral transmission. Our findings indicated that transmission primarily originated in South Korea’s metropolitan areas, and a positive correlation was observed between total human mobility (tracked by GPS on mobile phones and estimated through credit card consumption) and viral spread. The phylodynamic analysis further revealed that non-vaccinated individuals were the primary transmitters of the virus during the study period, even though vaccination programmes had commenced three months prior to the AY.69 outbreak. Our study emphasizes the need to focus on controlling SARS-CoV-2 transmission in metropolitan regions and among unvaccinated populations. Furthermore, the positive correlation between mobility data and viral dissemination could contribute to the development of more accurate predictive models for local spread of pandemics. |
| first_indexed | 2024-03-08T11:51:11Z |
| format | Article |
| id | doaj.art-388652e568fb4e21a6b72a5cc7d71eb2 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-24T22:31:21Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-388652e568fb4e21a6b72a5cc7d71eb22024-03-19T19:34:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2228934Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of KoreaSangyi Lee0Dong-Wook Lee1Jeong-Min Kim2Da-Won Kim3Ji-Yun Kim4Jeong-Ah Kim5Il-Hwan Kim6Jee Eun Rhee7Kyung-duk Min8Sung-il Cho9Eun-Jin Kim10Jung-Hoon Kwon11Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, Republic of KoreaDivision of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, Republic of KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, Republic of KoreaDivision of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of KoreaDivision of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of KoreaDivision of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of KoreaCollege of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of KoreaDepartment of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of KoreaDivision of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, Republic of KoreaABSTRACTFollowing the global emergence of the SARS-CoV-2 Alpha variant of concern (VOC) in 2020, the Delta variant triggered another wave in 2021. The AY.69 lineage, a Delta VOC, was particularly prevalent in Republic of Korea (South Korea) from May 2021 to January 2022, despite the synchronized implementation of vaccination programmes and non-pharmaceutical interventions (NPIs) such as social distancing. In this study, we used phylogeographic analysis combined with a generalized linear model (GLM) to examine the impact of human movement and vaccination on viral transmission. Our findings indicated that transmission primarily originated in South Korea’s metropolitan areas, and a positive correlation was observed between total human mobility (tracked by GPS on mobile phones and estimated through credit card consumption) and viral spread. The phylodynamic analysis further revealed that non-vaccinated individuals were the primary transmitters of the virus during the study period, even though vaccination programmes had commenced three months prior to the AY.69 outbreak. Our study emphasizes the need to focus on controlling SARS-CoV-2 transmission in metropolitan regions and among unvaccinated populations. Furthermore, the positive correlation between mobility data and viral dissemination could contribute to the development of more accurate predictive models for local spread of pandemics.https://www.tandfonline.com/doi/10.1080/22221751.2023.2228934SARS-CoV-2viral transmissionphylodynamicsvaccinationhuman mobility |
| spellingShingle | Sangyi Lee Dong-Wook Lee Jeong-Min Kim Da-Won Kim Ji-Yun Kim Jeong-Ah Kim Il-Hwan Kim Jee Eun Rhee Kyung-duk Min Sung-il Cho Eun-Jin Kim Jung-Hoon Kwon Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea Emerging Microbes and Infections SARS-CoV-2 viral transmission phylodynamics vaccination human mobility |
| title | Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea |
| title_full | Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea |
| title_fullStr | Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea |
| title_full_unstemmed | Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea |
| title_short | Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea |
| title_sort | phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of sars cov 2 in republic of korea |
| topic | SARS-CoV-2 viral transmission phylodynamics vaccination human mobility |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2228934 |
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