Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

Parkinson’s disease (PD) is characterised by dopaminergic neuronal loss in the brain area. PD is a complex disease that deteriorates patients’ motor and non-motor functions. In experimental animals, the neurotoxin 6-OHDA induces neuropathological, behavioural, neurochemical and mitochondrial abnorma...

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Bibliographic Details
Main Authors: Metab Alharbi, Abdulrahman Alshammari, Gurpreet Kaur, Sanjeev Kalra, Sidharth Mehan, Manisha Suri, Swesha Chhabra, Nitish Kumar, Wael A. Alanazi, Aliah R. Alshanwani, Abdullah Hamed AL-Ghamdi, Acharan S. Narula, Reni Kalfin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
adenylcyclase
CREB
forskolin
mitochondrial abnormalities
Parkinson’s disease
Online Access:https://www.mdpi.com/1420-3049/27/22/7951

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