Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac)
<i>Rhus coriaria</i> L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/1/73 |
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| author | Halima Alsamri Khawlah Athamneh Gianfranco Pintus Ali H. Eid Rabah Iratni |
| author_facet | Halima Alsamri Khawlah Athamneh Gianfranco Pintus Ali H. Eid Rabah Iratni |
| author_sort | Halima Alsamri |
| collection | DOAJ |
| description | <i>Rhus coriaria</i> L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and many others. By virtue of its bioactive, <i>Rhus coriaria</i> possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including cardiovascular disease, diabetes, and cancer. This review describes the phytochemical properties of <i>R. coriaria</i> and then focuses on the potent antioxidant capacities of sumac. We then dissect the cellular and molecular mechanisms of sumac’s action in modulating many pathophysiological instigators. We show how accumulating evidence supports the antibacterial, antinociceptive, antidiabetic, cardioprotective, neuroprotective, and anticancer effects of this plant, especially that toxicity studies show that sumac is very safe to consume by humans and has little toxicity. Taken together, the findings we summarize here support the utilization of this plant as an attractive target for drug discovery. |
| first_indexed | 2024-03-09T05:36:25Z |
| format | Article |
| id | doaj.art-3888c7b8e0f04d89a5b521528355f440 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:36:25Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3888c7b8e0f04d89a5b521528355f4402023-12-03T12:27:58ZengMDPI AGAntioxidants2076-39212021-01-011017310.3390/antiox10010073Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac)Halima Alsamri0Khawlah Athamneh1Gianfranco Pintus2Ali H. Eid3Rabah Iratni4Department of Biology, College of Science, United Arab Emirates University, Al-Ain 15551, UAEDepartment of Biology, College of Science, United Arab Emirates University, Al-Ain 15551, UAEDepartment of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah 27272, UAEDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha 2713, QatarDepartment of Biology, College of Science, United Arab Emirates University, Al-Ain 15551, UAE<i>Rhus coriaria</i> L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and many others. By virtue of its bioactive, <i>Rhus coriaria</i> possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including cardiovascular disease, diabetes, and cancer. This review describes the phytochemical properties of <i>R. coriaria</i> and then focuses on the potent antioxidant capacities of sumac. We then dissect the cellular and molecular mechanisms of sumac’s action in modulating many pathophysiological instigators. We show how accumulating evidence supports the antibacterial, antinociceptive, antidiabetic, cardioprotective, neuroprotective, and anticancer effects of this plant, especially that toxicity studies show that sumac is very safe to consume by humans and has little toxicity. Taken together, the findings we summarize here support the utilization of this plant as an attractive target for drug discovery.https://www.mdpi.com/2076-3921/10/1/73<i>Rhus coriaria</i>phytochemicalantioxidantanticancerantimicrobial |
| spellingShingle | Halima Alsamri Khawlah Athamneh Gianfranco Pintus Ali H. Eid Rabah Iratni Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) Antioxidants <i>Rhus coriaria</i> phytochemical antioxidant anticancer antimicrobial |
| title | Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) |
| title_full | Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) |
| title_fullStr | Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) |
| title_full_unstemmed | Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) |
| title_short | Pharmacological and Antioxidant Activities of <i>Rhus coriaria</i> L. (Sumac) |
| title_sort | pharmacological and antioxidant activities of i rhus coriaria i l sumac |
| topic | <i>Rhus coriaria</i> phytochemical antioxidant anticancer antimicrobial |
| url | https://www.mdpi.com/2076-3921/10/1/73 |
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