Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo

Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo

Abstract Loss of endoplasmic reticulum (ER) homeostasis leads to ER stress, thus prolonged activation can lead to apoptosis. Herein, artesunate (ART) induced ER stress in leukaemia cells, resulting in eIF2α phosphorylation, activation of transcription factor 4, subsequent CHOP upregulation and XBP1...

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Bibliographic Details
Main Authors: Rubia Isler Mancuso, Juliana Hofstätter Azambuja, Fernanda Soares Niemann, Ada Congrains, Mary Ann Foglio, Eduardo Magalhães Rego, Sara Teresinha Olalla Saad
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:eJHaem
Subjects:
acute leukaemia
artemisinin
artesunate
endoplasmic reticulum stress
Online Access:https://doi.org/10.1002/jha2.314

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