What is the optimal duration of middle-cerebral artery occlusion consistently resulting in isolated cortical selective neuronal loss in the spontaneously hypertensive rat?

What is the optimal duration of middle-cerebral artery occlusion consistently resulting in isolated cortical selective neuronal loss in the spontaneously hypertensive rat?

Introduction and Objectives: Selective neuronal loss (SNL) in the reperfused penumbra may impact clinical recovery and is thus important to investigate. Brief proximal middle cerebral artery occlusion (MCAo) results in predominantly striatal SNL, yet cortical damage is more relevant given its behavi...

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Bibliographic Details
Main Authors: Sohail eEjaz, David J Williamson, Ulf eJensen-Kondering, Tahir eAhmed, Stephen John Sawiak, Jean-Claude eBaron
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Neurology
Subjects:
Reperfusion
Stroke
rat models
focal cerebral ischemia
microglial activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00064/full

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