Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors
BackgroundVariations in the gut microbiota may affect the metabolism, inflammation and immune response of the host. Microbiota dysbiosis has been extensively investigated in neurological disorders and diseases of the central nervous system (CNS). However, the alterations of the gut microbiota in pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.881071/full |
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| author | Yuping Li Yuping Li Haixiao Jiang Xiaolin Wang Xiaoguang Liu Yujia Huang Zhiyao Wang Qiang Ma Lun Dong Yajie Qi Hengzhu Zhang Guangyu Lu |
| author_facet | Yuping Li Yuping Li Haixiao Jiang Xiaolin Wang Xiaoguang Liu Yujia Huang Zhiyao Wang Qiang Ma Lun Dong Yajie Qi Hengzhu Zhang Guangyu Lu |
| author_sort | Yuping Li |
| collection | DOAJ |
| description | BackgroundVariations in the gut microbiota may affect the metabolism, inflammation and immune response of the host. Microbiota dysbiosis has been extensively investigated in neurological disorders and diseases of the central nervous system (CNS). However, the alterations of the gut microbiota in patients suffering from brain tumors and the associations of the gut microbiota with these diseases remain unknown. Herein, we investigate the alterations of the gut microbiota community in patients with brain tumors and the associations between the two and further explore microbial markers used for the diagnosis of brain tumors.MethodsIn our study, we recruited 158 participants, consisting of 101 brain tumor patients (65 benign and 36 malignant cases) and 57 age- and sex-matched healthy controls (HCs). We characterized the gut microbial community by using 16S rRNA gene amplicon sequencing and investigated its correlations with clinical features.ResultsThe results showed remarkably less microbial ecosystem richness and evenness in patients with brain tumors than in HCs. The gut microbiota community structure underwent profound changes in the brain tumor group, including an increase in the abundances of pathogenic bacteria, such as Fusobacteriota and Proteobacteria and a reduction in the abundances of probiotic bacteria, such as Bifidobacterium or Lachnospira. Moreover, our study indicated more significant correlations and clustering of pathogens in the malignant brain tumor group. Furthermore, a biomarker panel was used to discriminate the brain tumor patients from the healthy controls (AUC: 0.77). Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation revealed an accumulation of harmful metabolites and disorders of the basic physiological pathways in the brain tumor group.ConclusionsOur study revealed that brain tumor patients may possess divergent host-microbe interactions from those of healthy controls, especially in malignant brain tumor patients. In addition, the intestinal flora may be involved in immune responses and metabolism in the microenvironment of brain tumors. All evidence, including the biomarker panel, suggests that the intestinal flora may be a useful diagnostic and predictive tool and an important preventive target for brain tumors. |
| first_indexed | 2024-12-12T13:06:15Z |
| format | Article |
| id | doaj.art-388983c915ad476f956ff1bbfff844d4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-12T13:06:15Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-388983c915ad476f956ff1bbfff844d42022-12-22T00:23:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.881071881071Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain TumorsYuping Li0Yuping Li1Haixiao Jiang2Xiaolin Wang3Xiaoguang Liu4Yujia Huang5Zhiyao Wang6Qiang Ma7Lun Dong8Yajie Qi9Hengzhu Zhang10Guangyu Lu11Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Neurosurgery, Yangzhou Clinical Medical College of Xuzhou Medical University, Xuzhou, ChinaDepartment of Neurosurgery, Affiliated Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Thoracic Surgery, Northern Jiangsu People’s Hospital, Clinical Medical College, Yangzhou University, Yangzhou, ChinaNeuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaNeuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaNeuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaNeuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaSchool of Public Health, Yangzhou University, Yangzhou, ChinaBackgroundVariations in the gut microbiota may affect the metabolism, inflammation and immune response of the host. Microbiota dysbiosis has been extensively investigated in neurological disorders and diseases of the central nervous system (CNS). However, the alterations of the gut microbiota in patients suffering from brain tumors and the associations of the gut microbiota with these diseases remain unknown. Herein, we investigate the alterations of the gut microbiota community in patients with brain tumors and the associations between the two and further explore microbial markers used for the diagnosis of brain tumors.MethodsIn our study, we recruited 158 participants, consisting of 101 brain tumor patients (65 benign and 36 malignant cases) and 57 age- and sex-matched healthy controls (HCs). We characterized the gut microbial community by using 16S rRNA gene amplicon sequencing and investigated its correlations with clinical features.ResultsThe results showed remarkably less microbial ecosystem richness and evenness in patients with brain tumors than in HCs. The gut microbiota community structure underwent profound changes in the brain tumor group, including an increase in the abundances of pathogenic bacteria, such as Fusobacteriota and Proteobacteria and a reduction in the abundances of probiotic bacteria, such as Bifidobacterium or Lachnospira. Moreover, our study indicated more significant correlations and clustering of pathogens in the malignant brain tumor group. Furthermore, a biomarker panel was used to discriminate the brain tumor patients from the healthy controls (AUC: 0.77). Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation revealed an accumulation of harmful metabolites and disorders of the basic physiological pathways in the brain tumor group.ConclusionsOur study revealed that brain tumor patients may possess divergent host-microbe interactions from those of healthy controls, especially in malignant brain tumor patients. In addition, the intestinal flora may be involved in immune responses and metabolism in the microenvironment of brain tumors. All evidence, including the biomarker panel, suggests that the intestinal flora may be a useful diagnostic and predictive tool and an important preventive target for brain tumors.https://www.frontiersin.org/articles/10.3389/fcimb.2022.881071/fullgut microbiomebiomarkermicrobiota-gut-immunebrain-gut axisbrain tumors |
| spellingShingle | Yuping Li Yuping Li Haixiao Jiang Xiaolin Wang Xiaoguang Liu Yujia Huang Zhiyao Wang Qiang Ma Lun Dong Yajie Qi Hengzhu Zhang Guangyu Lu Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors Frontiers in Cellular and Infection Microbiology gut microbiome biomarker microbiota-gut-immune brain-gut axis brain tumors |
| title | Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors |
| title_full | Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors |
| title_fullStr | Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors |
| title_full_unstemmed | Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors |
| title_short | Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors |
| title_sort | crosstalk between the gut and brain importance of the fecal microbiota in patient with brain tumors |
| topic | gut microbiome biomarker microbiota-gut-immune brain-gut axis brain tumors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.881071/full |
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