Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure
β-cell dedifferentiation is a key feature of type 2 diabetes. Here, the authors show evidence of re-differentiation of de-differentiated β-cells and identify ALDH1A3 as a key player in this process, proposing inhibition of ALDH1A3 as a treatment method for β-cell dysfunction in diabetes.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36315-4 |
| _version_ | 1811171616968671232 |
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| author | Jinsook Son Wen Du Mark Esposito Kaavian Shariati Hongxu Ding Yibin Kang Domenico Accili |
| author_facet | Jinsook Son Wen Du Mark Esposito Kaavian Shariati Hongxu Ding Yibin Kang Domenico Accili |
| author_sort | Jinsook Son |
| collection | DOAJ |
| description | β-cell dedifferentiation is a key feature of type 2 diabetes. Here, the authors show evidence of re-differentiation of de-differentiated β-cells and identify ALDH1A3 as a key player in this process, proposing inhibition of ALDH1A3 as a treatment method for β-cell dysfunction in diabetes. |
| first_indexed | 2024-04-10T17:17:03Z |
| format | Article |
| id | doaj.art-388d1bdb61fe476890cd14855d0fefa0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T17:17:03Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-388d1bdb61fe476890cd14855d0fefa02023-02-05T12:17:37ZengNature PortfolioNature Communications2041-17232023-02-0114111410.1038/s41467-023-36315-4Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failureJinsook Son0Wen Du1Mark Esposito2Kaavian Shariati3Hongxu Ding4Yibin Kang5Domenico Accili6Department of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia UniversityKayothera IncDepartment of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Pharmacy Practice & Science, College of Pharmacy, University of ArizonaDepartment of Molecular Biology, Princeton UniversityDepartment of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia Universityβ-cell dedifferentiation is a key feature of type 2 diabetes. Here, the authors show evidence of re-differentiation of de-differentiated β-cells and identify ALDH1A3 as a key player in this process, proposing inhibition of ALDH1A3 as a treatment method for β-cell dysfunction in diabetes.https://doi.org/10.1038/s41467-023-36315-4 |
| spellingShingle | Jinsook Son Wen Du Mark Esposito Kaavian Shariati Hongxu Ding Yibin Kang Domenico Accili Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure Nature Communications |
| title | Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure |
| title_full | Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure |
| title_fullStr | Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure |
| title_full_unstemmed | Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure |
| title_short | Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure |
| title_sort | genetic and pharmacologic inhibition of aldh1a3 as a treatment of β cell failure |
| url | https://doi.org/10.1038/s41467-023-36315-4 |
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