Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives

Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives

Abstract Several novel approaches to target Bcl-2 proteins and apoptotic pathways have been identified in recent years for the treatment of different types of cancer including colorectal cancer. However, no effective treatments were yet developed for colorectal cancer. Twenty two novel benzoxazole a...

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Bibliographic Details
Main Authors: Sama W. Helmy, Mai I. Shahin, Nermin Samir, Deena S. Lasheen, Dalal A. Abou El Ella
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Chemistry
Subjects:
Apoptosis
Bcl-2
Caspase
Benzoxazole
Thiazole
Colorectal cancer
Online Access:https://doi.org/10.1186/s13065-023-01101-2

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