A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗
Salmonella strains colonize the digestive tract of farm livestock, such as chickens or pigs, without affecting them, and potentially infect food products, representing a threat for human health ranging from food poisoning to typhoid fever. It has been shown that the ability to excrete the pathogen i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2020-01-01
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| Series: | ESAIM: Proceedings and Surveys |
| Online Access: | https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206715.pdf |
| _version_ | 1797969053534388224 |
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| author | Labarthe Simon Laroche Béatrice Nguyen Thi Nhu Thao Polizzi Bastien Patout Florian Ribot Magali Stegmaier Tabea |
| author_facet | Labarthe Simon Laroche Béatrice Nguyen Thi Nhu Thao Polizzi Bastien Patout Florian Ribot Magali Stegmaier Tabea |
| author_sort | Labarthe Simon |
| collection | DOAJ |
| description | Salmonella strains colonize the digestive tract of farm livestock, such as chickens or pigs, without affecting them, and potentially infect food products, representing a threat for human health ranging from food poisoning to typhoid fever. It has been shown that the ability to excrete the pathogen in the environment and contaminate other animals is variable. This heterogeneity in pathogen carriage and shedding results from interactions between the host’s immune response, the pathogen and the commensal intestinal microbiota. In this paper we propose a novel generic multiscale modeling framework of heterogeneous pathogen transmission in an animal population. At the intra-host level, the model describes the interaction between the commensal microbiota, the pathogen and the inflammatory response. Random fluctuations in the ecological dynamics of the individual microbiota and transmission at between-host scale are added to obtain a drift-diffusion PDE model of the pathogen distribution at the population level. The model is further extended to represent transmission between several populations. The asymptotic behavior as well as the impact of control strategies including cleaning and antimicrobial administration are investigated through numerical simulation. |
| first_indexed | 2024-04-11T02:56:05Z |
| format | Article |
| id | doaj.art-388dc5a2b44c41d589439377b10ef28d |
| institution | Directory Open Access Journal |
| issn | 2267-3059 |
| language | English |
| last_indexed | 2024-04-11T02:56:05Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | ESAIM: Proceedings and Surveys |
| spelling | doaj.art-388dc5a2b44c41d589439377b10ef28d2023-01-02T15:10:31ZengEDP SciencesESAIM: Proceedings and Surveys2267-30592020-01-016726128410.1051/proc/202067015proc206715A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗Labarthe Simon0Laroche Béatrice1Nguyen Thi Nhu Thao2Polizzi Bastien3Patout Florian4Ribot Magali5Stegmaier Tabea6MalAGE, INRA, Université Paris-SaclayMalAGE, INRA, Université Paris-SaclayLaboratoire de Mathématiques de Besanҫon, UMR CNRS 6623, Université Bourgogne Franche-ComtéUniversité Claude Bernard Lyon 1, CNRS UMR 5208, Institut Camille JordanUMPA, Ecole Normale Supérieure de Lyon, UMR CNRS 5669IDP, Université d’Orléans, Université de Tours, CNRS UMR 7013Interdisziplinären Forschungsgruppe zur Analyse biologischer Risiken, Universität HamburgSalmonella strains colonize the digestive tract of farm livestock, such as chickens or pigs, without affecting them, and potentially infect food products, representing a threat for human health ranging from food poisoning to typhoid fever. It has been shown that the ability to excrete the pathogen in the environment and contaminate other animals is variable. This heterogeneity in pathogen carriage and shedding results from interactions between the host’s immune response, the pathogen and the commensal intestinal microbiota. In this paper we propose a novel generic multiscale modeling framework of heterogeneous pathogen transmission in an animal population. At the intra-host level, the model describes the interaction between the commensal microbiota, the pathogen and the inflammatory response. Random fluctuations in the ecological dynamics of the individual microbiota and transmission at between-host scale are added to obtain a drift-diffusion PDE model of the pathogen distribution at the population level. The model is further extended to represent transmission between several populations. The asymptotic behavior as well as the impact of control strategies including cleaning and antimicrobial administration are investigated through numerical simulation.https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206715.pdf |
| spellingShingle | Labarthe Simon Laroche Béatrice Nguyen Thi Nhu Thao Polizzi Bastien Patout Florian Ribot Magali Stegmaier Tabea A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ ESAIM: Proceedings and Surveys |
| title | A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ |
| title_full | A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ |
| title_fullStr | A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ |
| title_full_unstemmed | A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ |
| title_short | A multi-scale epidemic model of Salmonella infection with heterogeneous shedding∗ |
| title_sort | multi scale epidemic model of salmonella infection with heterogeneous shedding∗ |
| url | https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206715.pdf |
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