Antipsychotic-Related Hypothermia: Five New Cases
Background: Hypothermia is a potentially fatal adverse effect of antipsychotic drug (APD) use. With only 69 cases described in the literature, the condition is considered rare.Methods: We describe five new cases, in which we estimated the role of clozapine, haloperidol, olanzapine, penfluridol, risp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00543/full |
| _version_ | 1818135304339456000 |
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| author | Cherryl Zonnenberg Jolien M. Bueno-de-Mesquita Dharmindredew Ramlal Jan Dirk Blom Jan Dirk Blom Jan Dirk Blom |
| author_facet | Cherryl Zonnenberg Jolien M. Bueno-de-Mesquita Dharmindredew Ramlal Jan Dirk Blom Jan Dirk Blom Jan Dirk Blom |
| author_sort | Cherryl Zonnenberg |
| collection | DOAJ |
| description | Background: Hypothermia is a potentially fatal adverse effect of antipsychotic drug (APD) use. With only 69 cases described in the literature, the condition is considered rare.Methods: We describe five new cases, in which we estimated the role of clozapine, haloperidol, olanzapine, penfluridol, risperidone, and zuclopentixol with the aid of two structured assessment tools.Results: In addition to APD use, all five patients described by us had been exposed to one or more additional predisposing factors for hypothermia. Therefore, with the aid of the assessment tools, the causal role of APDs was considered “possible” in four cases of moderate hypothermia and “doubtful” in the remaining one of mild hypothermia.Conclusion: Although the best way to detect APD-related hypothermia is measuring the body temperature for a duration of at least 7–10 days after the start (or a dose increase) of APDs, the use of assessment tools to identify additional predisposing factors for hypothermia and to thus establish their causal relationship with APD use would seem to be valuable for clinical decision-making (i.e., whether or not to discontinue APD use). Further research is needed to obtain reliable prevalence figures for APD-related hypothermia and its consequences, preferably in relation with physiological changes in body temperature. |
| first_indexed | 2024-12-11T09:22:23Z |
| format | Article |
| id | doaj.art-388e5298332b4bcc8f70374aea98859b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T09:22:23Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-388e5298332b4bcc8f70374aea98859b2022-12-22T01:13:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-07-011010.3389/fpsyt.2019.00543455047Antipsychotic-Related Hypothermia: Five New CasesCherryl Zonnenberg0Jolien M. Bueno-de-Mesquita1Dharmindredew Ramlal2Jan Dirk Blom3Jan Dirk Blom4Jan Dirk Blom5Parnassia Academy, Parnassia Psychiatric Institute, The Hague, NetherlandsParnassia Academy, Parnassia Psychiatric Institute, The Hague, NetherlandsParnassia Academy, Parnassia Psychiatric Institute, The Hague, NetherlandsParnassia Academy, Parnassia Psychiatric Institute, The Hague, NetherlandsFaculty of Social Sciences, Leiden University, Leiden, NetherlandsDepartment of Psychiatry, University of Groningen, Groningen, NetherlandsBackground: Hypothermia is a potentially fatal adverse effect of antipsychotic drug (APD) use. With only 69 cases described in the literature, the condition is considered rare.Methods: We describe five new cases, in which we estimated the role of clozapine, haloperidol, olanzapine, penfluridol, risperidone, and zuclopentixol with the aid of two structured assessment tools.Results: In addition to APD use, all five patients described by us had been exposed to one or more additional predisposing factors for hypothermia. Therefore, with the aid of the assessment tools, the causal role of APDs was considered “possible” in four cases of moderate hypothermia and “doubtful” in the remaining one of mild hypothermia.Conclusion: Although the best way to detect APD-related hypothermia is measuring the body temperature for a duration of at least 7–10 days after the start (or a dose increase) of APDs, the use of assessment tools to identify additional predisposing factors for hypothermia and to thus establish their causal relationship with APD use would seem to be valuable for clinical decision-making (i.e., whether or not to discontinue APD use). Further research is needed to obtain reliable prevalence figures for APD-related hypothermia and its consequences, preferably in relation with physiological changes in body temperature.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00543/fullbody temperatureneurolepticpharmacotherapypsychosisschizophreniaside effect |
| spellingShingle | Cherryl Zonnenberg Jolien M. Bueno-de-Mesquita Dharmindredew Ramlal Jan Dirk Blom Jan Dirk Blom Jan Dirk Blom Antipsychotic-Related Hypothermia: Five New Cases Frontiers in Psychiatry body temperature neuroleptic pharmacotherapy psychosis schizophrenia side effect |
| title | Antipsychotic-Related Hypothermia: Five New Cases |
| title_full | Antipsychotic-Related Hypothermia: Five New Cases |
| title_fullStr | Antipsychotic-Related Hypothermia: Five New Cases |
| title_full_unstemmed | Antipsychotic-Related Hypothermia: Five New Cases |
| title_short | Antipsychotic-Related Hypothermia: Five New Cases |
| title_sort | antipsychotic related hypothermia five new cases |
| topic | body temperature neuroleptic pharmacotherapy psychosis schizophrenia side effect |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00543/full |
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