Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA

Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA

Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired cell surface proteins. The interaction of nerve g...

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Bibliographic Details
Main Authors: Marco Marzulli, Bonnie L. Hall, Mingdi Zhang, William F. Goins, Justus B. Cohen, Joseph C. Glorioso
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
HSV
gene therapy
glycoprotein
vector targeting
TrkA
NGF
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300102X

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