Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors incl...

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Bibliographic Details
Main Authors: Barbara A Scholz, Marie L Harth-Hertle, Georg Malterer, Juergen Haas, Joachim Ellwart, Thomas F Schulz, Bettina Kempkes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3656114?pdf=render

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