The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

Summary: Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific Rbm8a knockout (Rbm8aKOMK) mice that exhibited marked thrombocytopenia, internal hemorrhage, and splenomegaly, providing evidence that genetic deficiency of Rbm8a causes a dis...

Full description

Bibliographic Details
Main Authors:	Chun-Hao Su, Wei-Ju Liao, Wei-Chi Ke, Ruey-Bing Yang, Woan-Yuh Tarn
Format:	Article
Language:	English
Published:	Elsevier 2021-11-01
Series:	iScience
Subjects:	Biological sciences Cell biology Functional aspects of cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221013390

Similar Items

Dynamic Malignant Wave of Ribosome-Insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit
by: Ki Hyung Kim, et al.
Published: (2020-05-01)

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
by: Xin Xu, et al.
Published: (2023-10-01)

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets
by: Pei Xuan Song, et al.
Published: (2022-05-01)

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration
by: Synne Arstad Bjørnestad, et al.
Published: (2022-05-01)

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia
by: Abrey J. Yeo, et al.
Published: (2021-01-01)

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
by: Pam Speight, et al.
Published: (2021-07-01)

Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation
by: Taro Okada, et al.
Published: (2021-11-01)

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
by: Anissa A. Widjaja, et al.
Published: (2022-08-01)

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology
by: Heng Wang, et al.
Published: (2020-06-01)

Contribution of septins to human platelet structure and function
by: Oleg V. Kim, et al.
Published: (2022-07-01)

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties
by: Keisuke Sato, et al.
Published: (2022-06-01)

Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway
by: Nian Wang, et al.
Published: (2023-08-01)

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production
by: Chen-Yi Wu, et al.
Published: (2021-12-01)

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
by: Chenggang Zhang, et al.
Published: (2023-01-01)

Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
by: Liang Guo, et al.
Published: (2021-11-01)

SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12
by: Yuan Ma, et al.
Published: (2020-08-01)

Effects of microtubule length and crowding on active microtubule network organization
by: Wei-Xiang Chew, et al.
Published: (2023-02-01)

Propagation dynamics of electrotactic motility in large epithelial cell sheets
by: Yan Zhang, et al.
Published: (2022-10-01)

Poroptosis: A form of cell death depending on plasma membrane nanopores formation
by: Hao Li, et al.
Published: (2022-06-01)

SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway
by: Kun Fang, et al.
Published: (2022-07-01)

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
by: Xiufei Cao, et al.
Published: (2022-07-01)

Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle
by: Ataur Katebi, et al.
Published: (2020-06-01)

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells
by: Samuel L. Junod, et al.
Published: (2023-08-01)

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin
by: Matthias Przyklenk, et al.
Published: (2022-10-01)

Differential N-terminal processing of beta and gamma actin
by: Li Chen, et al.
Published: (2022-10-01)

A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation
by: Sheng Li, et al.
Published: (2021-11-01)

Early satellite cell communication creates a permissive environment for long-term muscle growth
by: Kevin A. Murach, et al.
Published: (2021-04-01)

Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release
by: Natarin Caengprasath, et al.
Published: (2020-09-01)

Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation
by: Inbal Wortzel, et al.
Published: (2021-06-01)

Tricalbins Are Required for Non-vesicular Ceramide Transport at ER-Golgi Contacts and Modulate Lipid Droplet Biogenesis
by: Atsuko Ikeda, et al.
Published: (2020-10-01)

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
by: Xin Chen, et al.
Published: (2021-12-01)

Super-resolution microscopy reveals nanoscale architecture and regulation of podosome clusters in primary macrophages
by: Fen Hu, et al.
Published: (2022-12-01)

mRNA splicing is modulated by intronic microRNAs
by: Luba Farberov, et al.
Published: (2023-10-01)

How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining
by: Patrick Streb, et al.
Published: (2023-06-01)

Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization
by: M.A. Neginskaya, et al.
Published: (2022-11-01)

Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
by: Arlinda Dullovi, et al.
Published: (2023-03-01)

Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding
by: Shuyan Yang, et al.
Published: (2022-06-01)

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
by: Erica R. Gansemer, et al.
Published: (2020-05-01)

Assembly and stability of IFT-B complex and its function in BBSome trafficking
by: Jieling Wang, et al.
Published: (2022-12-01)

Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide
by: Asako Goto, et al.
Published: (2022-07-01)