Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy
Application of drug conjugated iron oxide hematite ( α -Fe _2 O _3 ) nanoparticles are of tremendous interest in biomedicine nowadays. Meanwhile, green production of iron oxide nanoparticles is gaining favour due to its sustainability, ease of usage, and biocompatibility. Therefore, this work report...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2024-01-01
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| Series: | Nano Express |
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| Online Access: | https://doi.org/10.1088/2632-959X/ad2997 |
| _version_ | 1797290392880676864 |
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| author | Vandana Sharma J K Sharma Vishal Kansay Aarzoo Dutta Mayank Raj Manoj Singh Anu Kapoor Chhavi Pahwa Anupam Sharma Suresh Kumar A K Sharma M K Bera |
| author_facet | Vandana Sharma J K Sharma Vishal Kansay Aarzoo Dutta Mayank Raj Manoj Singh Anu Kapoor Chhavi Pahwa Anupam Sharma Suresh Kumar A K Sharma M K Bera |
| author_sort | Vandana Sharma |
| collection | DOAJ |
| description | Application of drug conjugated iron oxide hematite ( α -Fe _2 O _3 ) nanoparticles are of tremendous interest in biomedicine nowadays. Meanwhile, green production of iron oxide nanoparticles is gaining favour due to its sustainability, ease of usage, and biocompatibility. Therefore, this work reports on the use of hexahydrate ferric chloride and nerium oleander flower extract to synthesize nanoscaled hematite ( α -Fe _2 O _3 ) iron oxide particles conjugated with various drugs for antibacterial agents. Diverse morphological, physicochemical, structural, optical, and magnetic characteristics have been characterized using FESEM, EDX, XRD, UV–vis, FTIR, Raman and vibrating sample magnetometer. The synthesis of the polyshaped iron oxide nanoparticles, with average sizes ranging from 47.2 ± 20 nm, was accomplished. Furthermore, temperature-dependent variations in magnetic behavior were observed during calcination. The XRD and Raman spectra revealed hematite ( α -Fe _2 O _3 ) type formation of iron oxide nanoparticles. Only calcinated IO-NPs at high temperatures (700 °C) demonstrated low coercivity and residual magnetism, which revealed weak ferromagnetic ordering; other calcinated samples, including nascent ones, showed incredibly weak ferromagnetic ordering. Besides, the effectiveness of drug-encapsulated iron oxide nanoparticles against bacteria in vitro was examined. It was interesting to observe that gentamycin-coated IO-NPs tended to be more susceptible to S. aureus than E. coli bacteria, but streptomycin-conjugated IO-NPs showed the reverse trend. However, as compared to the nascent sample and the high temperature (700 °C) calcinated sample, both antibiotic-loaded IO-NPs displayed better inhibitory abilities. |
| first_indexed | 2024-03-07T19:21:43Z |
| format | Article |
| id | doaj.art-38911473698d457d9ce8268d8bdc6eb0 |
| institution | Directory Open Access Journal |
| issn | 2632-959X |
| language | English |
| last_indexed | 2024-03-07T19:21:43Z |
| publishDate | 2024-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Nano Express |
| spelling | doaj.art-38911473698d457d9ce8268d8bdc6eb02024-02-29T09:39:36ZengIOP PublishingNano Express2632-959X2024-01-015101501410.1088/2632-959X/ad2997Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacyVandana Sharma0J K Sharma1Vishal Kansay2Aarzoo Dutta3Mayank Raj4Manoj Singh5Anu Kapoor6Chhavi Pahwa7Anupam Sharma8Suresh Kumar9https://orcid.org/0000-0002-1623-3349A K Sharma10M K Bera11https://orcid.org/0000-0002-2996-890XDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaDepartment of Biotechnology, MM Engineering College, Maharishi Markandeshwar (Deemed to be University) , Mullana. Ambala (133207), Haryana, IndiaDepartment of Biotechnology, MM Engineering College, Maharishi Markandeshwar (Deemed to be University) , Mullana. Ambala (133207), Haryana, IndiaDeptt. of Physics, Chandigarh University , Gharaun, Mohali (140413), Punjab, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaMMIS, Maharishi Markandeshwar (Deemed to be University) , Mullana. Ambala (133207), Haryana, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaDepartment of Biotechnology, Amity University , Mohali (140306), Punjab, IndiaDepartment of Physics, MM Engineering College, Maharishi Markandeshwar ( Deemed to be University ), Mullana. Ambala (133207), Haryana, IndiaApplication of drug conjugated iron oxide hematite ( α -Fe _2 O _3 ) nanoparticles are of tremendous interest in biomedicine nowadays. Meanwhile, green production of iron oxide nanoparticles is gaining favour due to its sustainability, ease of usage, and biocompatibility. Therefore, this work reports on the use of hexahydrate ferric chloride and nerium oleander flower extract to synthesize nanoscaled hematite ( α -Fe _2 O _3 ) iron oxide particles conjugated with various drugs for antibacterial agents. Diverse morphological, physicochemical, structural, optical, and magnetic characteristics have been characterized using FESEM, EDX, XRD, UV–vis, FTIR, Raman and vibrating sample magnetometer. The synthesis of the polyshaped iron oxide nanoparticles, with average sizes ranging from 47.2 ± 20 nm, was accomplished. Furthermore, temperature-dependent variations in magnetic behavior were observed during calcination. The XRD and Raman spectra revealed hematite ( α -Fe _2 O _3 ) type formation of iron oxide nanoparticles. Only calcinated IO-NPs at high temperatures (700 °C) demonstrated low coercivity and residual magnetism, which revealed weak ferromagnetic ordering; other calcinated samples, including nascent ones, showed incredibly weak ferromagnetic ordering. Besides, the effectiveness of drug-encapsulated iron oxide nanoparticles against bacteria in vitro was examined. It was interesting to observe that gentamycin-coated IO-NPs tended to be more susceptible to S. aureus than E. coli bacteria, but streptomycin-conjugated IO-NPs showed the reverse trend. However, as compared to the nascent sample and the high temperature (700 °C) calcinated sample, both antibiotic-loaded IO-NPs displayed better inhibitory abilities.https://doi.org/10.1088/2632-959X/ad2997iron oxide nanoparticlesnerium oleandergreen synthesisantibacterial efficacystreptomycingentamycin |
| spellingShingle | Vandana Sharma J K Sharma Vishal Kansay Aarzoo Dutta Mayank Raj Manoj Singh Anu Kapoor Chhavi Pahwa Anupam Sharma Suresh Kumar A K Sharma M K Bera Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy Nano Express iron oxide nanoparticles nerium oleander green synthesis antibacterial efficacy streptomycin gentamycin |
| title | Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| title_full | Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| title_fullStr | Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| title_full_unstemmed | Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| title_short | Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| title_sort | green synthesis characterization and drug loaded iron oxide nanoparticles derived from nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy |
| topic | iron oxide nanoparticles nerium oleander green synthesis antibacterial efficacy streptomycin gentamycin |
| url | https://doi.org/10.1088/2632-959X/ad2997 |
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