Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly

Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly

TOR is a serine/threonine protein kinase that assembles into distinct TOR Complexes 1 and 2 (TORC1 or TORC2) to regulate cell growth. In mammalian cells, a single mTOR incorporates stably into mTORC1 and mTORC2. By contrast, in Saccharomyces cerevisiae, two highly similar Tor1 and Tor2 proteins exis...

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Bibliographic Details
Main Authors: Andrew Hill, Brad Niles, Andrew Cuyegkeng, Ted Powers
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Biomolecules
Subjects:
HEAT repeats
mTOR pathway
rapamycin
AGC kinases
Online Access:http://www.mdpi.com/2218-273X/8/2/36

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