Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their poten...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016423002670 |
| _version_ | 1797435714212724736 |
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| author | Ratnaningsih Eko Sardjono Ramdhan Gunawan Asep Kadarohman Erdiwansyah Rizalman Mamat Melati Khairuddean |
| author_facet | Ratnaningsih Eko Sardjono Ramdhan Gunawan Asep Kadarohman Erdiwansyah Rizalman Mamat Melati Khairuddean |
| author_sort | Ratnaningsih Eko Sardjono |
| collection | DOAJ |
| description | Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%. |
| first_indexed | 2024-03-09T10:52:13Z |
| format | Article |
| id | doaj.art-38939f357cbe491b996c8aca181593de |
| institution | Directory Open Access Journal |
| issn | 2666-0164 |
| language | English |
| last_indexed | 2024-03-09T10:52:13Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj.art-38939f357cbe491b996c8aca181593de2023-12-01T05:03:02ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642024-06-019100562Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drugRatnaningsih Eko Sardjono0Ramdhan Gunawan1Asep Kadarohman2 Erdiwansyah3Rizalman Mamat4Melati Khairuddean5Chemistry Program, Universitas Pendidikan Indonesia, Setiabudi 229, Bandung, 40154, Indonesia; Corresponding author.Chemistry Program, Universitas Pendidikan Indonesia, Setiabudi 229, Bandung, 40154, IndonesiaChemistry Program, Universitas Pendidikan Indonesia, Setiabudi 229, Bandung, 40154, IndonesiaFaculty of Engineering, Universitas Serambi Mekkah, Banda Aceh, 23245, Indonesia; Centre for Automotive Engineering, Universiti Malaysia Pahang, 26600, Pekan, Malaysia; Corresponding author. Faculty of Engineering, Universitas Serambi Mekkah, Banda Aceh, 23245, Indonesia.Centre for Automotive Engineering, Universiti Malaysia Pahang, 26600, Pekan, MalaysiaSchool of Chemical Sciences, Universiti Sains Malaysia, 11800, Penang, MalaysiaParkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%.http://www.sciencedirect.com/science/article/pii/S2666016423002670Anti–ParkinsonMucuna pruriensNanoencapsulationNanostarchParkinson's disease |
| spellingShingle | Ratnaningsih Eko Sardjono Ramdhan Gunawan Asep Kadarohman Erdiwansyah Rizalman Mamat Melati Khairuddean Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug Case Studies in Chemical and Environmental Engineering Anti–Parkinson Mucuna pruriens Nanoencapsulation Nanostarch Parkinson's disease |
| title | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_full | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_fullStr | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_full_unstemmed | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_short | Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug |
| title_sort | nanostarch based nanoencapsulation of mucuna pruriens extract and its evaluation as anti parkinsonian drug |
| topic | Anti–Parkinson Mucuna pruriens Nanoencapsulation Nanostarch Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2666016423002670 |
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