New Insights into Diffuse Large B-Cell Lymphoma Pathobiology
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we analyzed the role of different ce...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/7/1869 |
| _version_ | 1797562681065996288 |
|---|---|
| author | Antonio Giovanni Solimando Tiziana Annese Roberto Tamma Giuseppe Ingravallo Eugenio Maiorano Angelo Vacca Giorgina Specchia Domenico Ribatti |
| author_facet | Antonio Giovanni Solimando Tiziana Annese Roberto Tamma Giuseppe Ingravallo Eugenio Maiorano Angelo Vacca Giorgina Specchia Domenico Ribatti |
| author_sort | Antonio Giovanni Solimando |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we analyzed the role of different cellular components of the tumor microenvironment, including mast cells, macrophages, and lymphocytes, in the tumor progression of DLBCL. We examined several approaches to confront the available pieces of evidence, whereby three key points emerged. DLBCL is a disease of malignant B cells spreading and accumulating both at nodal and at extranodal sites. In patients with both nodal and extranodal lesions, the subsequent induction of a cancer-friendly environment appears pivotal. The DLBCL cell interaction with mature stromal cells and vessels confers tumor protection and inhibition of immune response while delivering nutrients and oxygen supply. Single cells may also reside and survive in protected niches in the nodal and extranodal sites as a source for residual disease and relapse. This review aims to molecularly and functionally recapitulate the DLBCL–milieu crosstalk, to relate niche and pathological angiogenic constitution and interaction factors to DLBCL progression. |
| first_indexed | 2024-03-10T18:32:25Z |
| format | Article |
| id | doaj.art-3895832f9c4d4d73b6a8140165bfbba7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:32:25Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3895832f9c4d4d73b6a8140165bfbba72023-11-20T06:30:22ZengMDPI AGCancers2072-66942020-07-01127186910.3390/cancers12071869New Insights into Diffuse Large B-Cell Lymphoma PathobiologyAntonio Giovanni Solimando0Tiziana Annese1Roberto Tamma2Giuseppe Ingravallo3Eugenio Maiorano4Angelo Vacca5Giorgina Specchia6Domenico Ribatti7Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine ‘G. Baccelli’, University of Bari Medical School, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, 70124 Bari, ItalyDepartment of Emergency and Transplantation, Pathology Section, University of Bari Medical School, 70100 Bari, ItalyDepartment of Emergency and Transplantation, Pathology Section, University of Bari Medical School, 70100 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine ‘G. Baccelli’, University of Bari Medical School, 70124 Bari, ItalyDepartment of Emergency and Transplantation, Hematology Section, University of Bari Medical School, 70100 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, 70124 Bari, ItalyDiffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we analyzed the role of different cellular components of the tumor microenvironment, including mast cells, macrophages, and lymphocytes, in the tumor progression of DLBCL. We examined several approaches to confront the available pieces of evidence, whereby three key points emerged. DLBCL is a disease of malignant B cells spreading and accumulating both at nodal and at extranodal sites. In patients with both nodal and extranodal lesions, the subsequent induction of a cancer-friendly environment appears pivotal. The DLBCL cell interaction with mature stromal cells and vessels confers tumor protection and inhibition of immune response while delivering nutrients and oxygen supply. Single cells may also reside and survive in protected niches in the nodal and extranodal sites as a source for residual disease and relapse. This review aims to molecularly and functionally recapitulate the DLBCL–milieu crosstalk, to relate niche and pathological angiogenic constitution and interaction factors to DLBCL progression.https://www.mdpi.com/2072-6694/12/7/1869DLBCLtumor microenvironmentangiogenesiscell adhesion mediated drug resistancetumor progression |
| spellingShingle | Antonio Giovanni Solimando Tiziana Annese Roberto Tamma Giuseppe Ingravallo Eugenio Maiorano Angelo Vacca Giorgina Specchia Domenico Ribatti New Insights into Diffuse Large B-Cell Lymphoma Pathobiology Cancers DLBCL tumor microenvironment angiogenesis cell adhesion mediated drug resistance tumor progression |
| title | New Insights into Diffuse Large B-Cell Lymphoma Pathobiology |
| title_full | New Insights into Diffuse Large B-Cell Lymphoma Pathobiology |
| title_fullStr | New Insights into Diffuse Large B-Cell Lymphoma Pathobiology |
| title_full_unstemmed | New Insights into Diffuse Large B-Cell Lymphoma Pathobiology |
| title_short | New Insights into Diffuse Large B-Cell Lymphoma Pathobiology |
| title_sort | new insights into diffuse large b cell lymphoma pathobiology |
| topic | DLBCL tumor microenvironment angiogenesis cell adhesion mediated drug resistance tumor progression |
| url | https://www.mdpi.com/2072-6694/12/7/1869 |
| work_keys_str_mv | AT antoniogiovannisolimando newinsightsintodiffuselargebcelllymphomapathobiology AT tizianaannese newinsightsintodiffuselargebcelllymphomapathobiology AT robertotamma newinsightsintodiffuselargebcelllymphomapathobiology AT giuseppeingravallo newinsightsintodiffuselargebcelllymphomapathobiology AT eugeniomaiorano newinsightsintodiffuselargebcelllymphomapathobiology AT angelovacca newinsightsintodiffuselargebcelllymphomapathobiology AT giorginaspecchia newinsightsintodiffuselargebcelllymphomapathobiology AT domenicoribatti newinsightsintodiffuselargebcelllymphomapathobiology |