Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial RegenerationSummary

Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial RegenerationSummary

Background and aims: Active intestinal stem cells are prone to injury by ionizing radiation. We previously showed that upon radiation-induced injury, normally quiescent reserve intestinal stem cells (rISCs) (marked by BMI1) are activated by Musashi-1 (MSI1) and exit from the quiescent state to regen...

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Bibliographic Details
Main Authors: Emilia J. Orzechowska-Licari, Agnieszka B. Bialkowska, Vincent W. Yang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Sonic Hedgehog
WNT Signaling
MSI1
GLI1
Intestinal Epithelium
Regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X23001315

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