Emerging Targets in Type 2 Diabetes and Diabetic Complications
Abstract Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed dia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202100275 |
| _version_ | 1818738263741956096 |
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| author | Sevgican Demir Peter P. Nawroth Stephan Herzig Bilgen Ekim Üstünel |
| author_facet | Sevgican Demir Peter P. Nawroth Stephan Herzig Bilgen Ekim Üstünel |
| author_sort | Sevgican Demir |
| collection | DOAJ |
| description | Abstract Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications. |
| first_indexed | 2024-12-18T01:06:10Z |
| format | Article |
| id | doaj.art-3896f6dd654f403aa07fd794b0829b1f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-18T01:06:10Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-3896f6dd654f403aa07fd794b0829b1f2022-12-21T21:26:13ZengWileyAdvanced Science2198-38442021-09-01818n/an/a10.1002/advs.202100275Emerging Targets in Type 2 Diabetes and Diabetic ComplicationsSevgican Demir0Peter P. Nawroth1Stephan Herzig2Bilgen Ekim Üstünel3Institute for Diabetes and Cancer (IDC) Helmholtz Center Munich Ingolstädter Landstr. 1 Neuherberg 85764 GermanyInstitute for Diabetes and Cancer (IDC) Helmholtz Center Munich Ingolstädter Landstr. 1 Neuherberg 85764 GermanyInstitute for Diabetes and Cancer (IDC) Helmholtz Center Munich Ingolstädter Landstr. 1 Neuherberg 85764 GermanyInstitute for Diabetes and Cancer (IDC) Helmholtz Center Munich Ingolstädter Landstr. 1 Neuherberg 85764 GermanyAbstract Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications.https://doi.org/10.1002/advs.202100275type 2 diabetes, diabetic complicationsinsulin resistancemetabolismsignaling pathways |
| spellingShingle | Sevgican Demir Peter P. Nawroth Stephan Herzig Bilgen Ekim Üstünel Emerging Targets in Type 2 Diabetes and Diabetic Complications Advanced Science type 2 diabetes, diabetic complications insulin resistance metabolism signaling pathways |
| title | Emerging Targets in Type 2 Diabetes and Diabetic Complications |
| title_full | Emerging Targets in Type 2 Diabetes and Diabetic Complications |
| title_fullStr | Emerging Targets in Type 2 Diabetes and Diabetic Complications |
| title_full_unstemmed | Emerging Targets in Type 2 Diabetes and Diabetic Complications |
| title_short | Emerging Targets in Type 2 Diabetes and Diabetic Complications |
| title_sort | emerging targets in type 2 diabetes and diabetic complications |
| topic | type 2 diabetes, diabetic complications insulin resistance metabolism signaling pathways |
| url | https://doi.org/10.1002/advs.202100275 |
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