Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population
ABSTRACT: Objectives: To examine prevalence and risk factors for post-COVID-19 condition (PCC) in a paediatric population. Methods: The study included patients aged 5-17 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between 1 March 2021 and 30 April 2022 and matc...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224000791 |
| _version_ | 1797220585814622208 |
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| author | Mariko Hosozawa Miyuki Hori Mina Hayama-Terada Iba Arisa Yoko Muto Akihiko Kitamura Yoshihiro Takayama Hiroyasu Iso |
| author_facet | Mariko Hosozawa Miyuki Hori Mina Hayama-Terada Iba Arisa Yoko Muto Akihiko Kitamura Yoshihiro Takayama Hiroyasu Iso |
| author_sort | Mariko Hosozawa |
| collection | DOAJ |
| description | ABSTRACT: Objectives: To examine prevalence and risk factors for post-COVID-19 condition (PCC) in a paediatric population. Methods: The study included patients aged 5-17 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between 1 March 2021 and 30 April 2022 and matched non-infected controls from Yao City, Japan. We compared parent-reported symptoms persisting ≥2 months (present at 3 months post-infection for patients) between the groups. COVID-19 vaccination data was obtained from the Vaccination Registry. Results: Among 8167 invited individuals, 3141 (1800 cases, mean age: 10.4 years, 46.1% females; 1341 controls, mean age 10.5 years, 47.1% females) participated. Patients had elapsed average 273 (185-605) days from infection, and 1708 (94.9%) experienced mild acute symptoms. Patients had higher odds of having persistent symptoms than did controls (6.3% vs 2.2%, adjusted odds ratio [aOR]: 3.15, 95% confidence interval: 2.08-4.77), with 53.6% of them reporting current disruption due to the symptoms. Older age, low household income, pre-existing allergy, and autonomic nervous system disease were associated with increased risks of developing PCC; two prior vaccination doses reduced these risks (aOR: 0.52, 0.29-0.93). Conclusion: SARS-CoV-2 infection, including omicron infections heighten persistent symptom risk in the paediatric population, necessitating preventive strategies, notably vaccination. |
| first_indexed | 2024-04-24T12:51:53Z |
| format | Article |
| id | doaj.art-3897f33ac6b94ab5b2707d09b5358e7b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-24T12:51:53Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-3897f33ac6b94ab5b2707d09b5358e7b2024-04-06T04:39:34ZengElsevierInternational Journal of Infectious Diseases1201-97122024-06-01143107008Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general populationMariko Hosozawa0Miyuki Hori1Mina Hayama-Terada2Iba Arisa3Yoko Muto4Akihiko Kitamura5Yoshihiro Takayama6Hiroyasu Iso7Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan; Corresponding author: Mariko Hosozawa, Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjukuku, Tokyo, 162-8655, Japan.Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, JapanYao City Public Health Center, Osaka, JapanInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, JapanInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, JapanYao City Public Health Center, Osaka, JapanYao City Public Health Center, Osaka, JapanInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, JapanABSTRACT: Objectives: To examine prevalence and risk factors for post-COVID-19 condition (PCC) in a paediatric population. Methods: The study included patients aged 5-17 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between 1 March 2021 and 30 April 2022 and matched non-infected controls from Yao City, Japan. We compared parent-reported symptoms persisting ≥2 months (present at 3 months post-infection for patients) between the groups. COVID-19 vaccination data was obtained from the Vaccination Registry. Results: Among 8167 invited individuals, 3141 (1800 cases, mean age: 10.4 years, 46.1% females; 1341 controls, mean age 10.5 years, 47.1% females) participated. Patients had elapsed average 273 (185-605) days from infection, and 1708 (94.9%) experienced mild acute symptoms. Patients had higher odds of having persistent symptoms than did controls (6.3% vs 2.2%, adjusted odds ratio [aOR]: 3.15, 95% confidence interval: 2.08-4.77), with 53.6% of them reporting current disruption due to the symptoms. Older age, low household income, pre-existing allergy, and autonomic nervous system disease were associated with increased risks of developing PCC; two prior vaccination doses reduced these risks (aOR: 0.52, 0.29-0.93). Conclusion: SARS-CoV-2 infection, including omicron infections heighten persistent symptom risk in the paediatric population, necessitating preventive strategies, notably vaccination.http://www.sciencedirect.com/science/article/pii/S1201971224000791SARS-CoV-2Long COVIDPost-COVID-19 conditionCase-control studyCOVID-19 vaccine |
| spellingShingle | Mariko Hosozawa Miyuki Hori Mina Hayama-Terada Iba Arisa Yoko Muto Akihiko Kitamura Yoshihiro Takayama Hiroyasu Iso Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population International Journal of Infectious Diseases SARS-CoV-2 Long COVID Post-COVID-19 condition Case-control study COVID-19 vaccine |
| title | Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population |
| title_full | Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population |
| title_fullStr | Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population |
| title_full_unstemmed | Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population |
| title_short | Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population |
| title_sort | prevalence and risk factors of post coronavirus disease 2019 condition among children and adolescents in japan a matched case control study in the general population |
| topic | SARS-CoV-2 Long COVID Post-COVID-19 condition Case-control study COVID-19 vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224000791 |
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