Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA
Previously, we developed a novel model for anxiety during motivated behavior by training rats to perform a task where actions executed to obtain a reward were probabilistically punished and observed that after learning, neuronal activity in the ventral tegmental area (VTA) and dorsomedial prefrontal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/78912 |
| _version_ | 1811208033142833152 |
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| author | David S Jacobs Madeleine C Allen Junchol Park Bita Moghaddam |
| author_facet | David S Jacobs Madeleine C Allen Junchol Park Bita Moghaddam |
| author_sort | David S Jacobs |
| collection | DOAJ |
| description | Previously, we developed a novel model for anxiety during motivated behavior by training rats to perform a task where actions executed to obtain a reward were probabilistically punished and observed that after learning, neuronal activity in the ventral tegmental area (VTA) and dorsomedial prefrontal cortex (dmPFC) represent the relationship between action and punishment risk (Park and Moghaddam, 2017). Here, we used male and female rats to expand on the previous work by focusing on neural changes in the dmPFC and VTA that were associated with the learning of probabilistic punishment, and anxiolytic treatment with diazepam after learning. We find that adaptive neural responses of dmPFC and VTA during the learning of anxiogenic contingencies are independent from the punisher experience and occur primarily during the peri-action and reward period. Our results also identify peri-action ramping of VTA neural calcium activity, and VTA-dmPFC correlated activity, as potential markers for the anxiolytic properties of diazepam. |
| first_indexed | 2024-04-12T04:15:26Z |
| format | Article |
| id | doaj.art-3897f6113b7847e982f06a713a65c556 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T04:15:26Z |
| publishDate | 2022-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3897f6113b7847e982f06a713a65c5562022-12-22T03:48:24ZengeLife Sciences Publications LtdeLife2050-084X2022-09-011110.7554/eLife.78912Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTADavid S Jacobs0https://orcid.org/0000-0003-3560-7307Madeleine C Allen1Junchol Park2https://orcid.org/0000-0002-4739-0793Bita Moghaddam3https://orcid.org/0000-0002-5205-417XDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, United StatesDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, United States; Department of Psychiatry, Oregon Health & Science University, Portland, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, United States; Department of Psychiatry, Oregon Health & Science University, Portland, United StatesPreviously, we developed a novel model for anxiety during motivated behavior by training rats to perform a task where actions executed to obtain a reward were probabilistically punished and observed that after learning, neuronal activity in the ventral tegmental area (VTA) and dorsomedial prefrontal cortex (dmPFC) represent the relationship between action and punishment risk (Park and Moghaddam, 2017). Here, we used male and female rats to expand on the previous work by focusing on neural changes in the dmPFC and VTA that were associated with the learning of probabilistic punishment, and anxiolytic treatment with diazepam after learning. We find that adaptive neural responses of dmPFC and VTA during the learning of anxiogenic contingencies are independent from the punisher experience and occur primarily during the peri-action and reward period. Our results also identify peri-action ramping of VTA neural calcium activity, and VTA-dmPFC correlated activity, as potential markers for the anxiolytic properties of diazepam.https://elifesciences.org/articles/78912anxietylearningprefrontal cortexdopaminerewardpunishment |
| spellingShingle | David S Jacobs Madeleine C Allen Junchol Park Bita Moghaddam Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA eLife anxiety learning prefrontal cortex dopamine reward punishment |
| title | Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA |
| title_full | Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA |
| title_fullStr | Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA |
| title_full_unstemmed | Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA |
| title_short | Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA |
| title_sort | learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmpfc and vta |
| topic | anxiety learning prefrontal cortex dopamine reward punishment |
| url | https://elifesciences.org/articles/78912 |
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