Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER–ERK–NF-κB signaling pathway

Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER–ERK–NF-κB signaling pathway

Abstract Background Activated microglia play a key role in initiating the inflammatory cascade following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending on whether they are polarized toward the M1 or M2 phenotype. The present study investigated the regulatory effect...

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Bibliographic Details
Main Authors: Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Medicine
Subjects:
Cerebral ischemia/reperfusion injury
Icaritin
Microglia
GPER
ERK
NF-κB
Online Access:https://doi.org/10.1186/s10020-022-00573-7

Internet

https://doi.org/10.1186/s10020-022-00573-7

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