Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China
In recent years, the incidence of varicella cases is rising, and outbreaks of varicella are frequently being reported worldwide. Our study aims to analyze the association between the varicella incidence and serum antibody level in the post-vaccine era. We retrieved and analyzed the incidence and pre...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-02-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1775458 |
| _version_ | 1797677269216395264 |
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| author | Qi Liu Jiake Yu Jingjiao Wei Hu Zhang Jie Jin Weikun Zheng Yufei Ruan Jinsheng Yu Yiping Chen |
| author_facet | Qi Liu Jiake Yu Jingjiao Wei Hu Zhang Jie Jin Weikun Zheng Yufei Ruan Jinsheng Yu Yiping Chen |
| author_sort | Qi Liu |
| collection | DOAJ |
| description | In recent years, the incidence of varicella cases is rising, and outbreaks of varicella are frequently being reported worldwide. Our study aims to analyze the association between the varicella incidence and serum antibody level in the post-vaccine era. We retrieved and analyzed the incidence and prevalence data for children age 1–14 years in Wenzhou, China during 2010–2018. A cross-sectional seroepidemiology analysis was carried out in a series of 168 general healthy children age 1–14 years as well as children at a varicella outbreak in Wenzhou. Our data showed a significant surge in the incidence and prevalence of varicella in children aged 10–14 years in 2017 and 2018 while they were kept relatively stable in 2010–2016. The seroepidemiological analysis revealed a 7.3-fold significantly higher level of serum varicella IgG in healthy control students who exposed at the outbreak than that in general healthy children (median 523.5 vs. 71.7 mIU/mL, p < .01). The children 10–14 years old had the lowest rate of second-dose vaccination among the three age classes (7%, 41%, and 65% in 10–14, 5–9, and 2–4 age class, respectively), and children 5–9 years old who received the second dose had a higher level of serum protective IgG than those who did not (254.7 vs 98 mIU/mL, p = .06). The findings from the present study warn a two-dose vaccine schedule to reduce the climbing incidence and prevalence observed in the older children and suggest a higher serum IgG threshold for effective protection of children from the varicella outbreak. |
| first_indexed | 2024-03-11T22:42:31Z |
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| id | doaj.art-389a3095d7dc4ef4b12fda3b8104b815 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:42:31Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-389a3095d7dc4ef4b12fda3b8104b8152023-09-22T08:51:49ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-02-0117236337110.1080/21645515.2020.17754581775458Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, ChinaQi Liu0Jiake Yu1Jingjiao Wei2Hu Zhang3Jie Jin4Weikun Zheng5Yufei Ruan6Jinsheng Yu7Yiping Chen8The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityZhejiang Center for Disease Control and PreventionThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical UniversityIn recent years, the incidence of varicella cases is rising, and outbreaks of varicella are frequently being reported worldwide. Our study aims to analyze the association between the varicella incidence and serum antibody level in the post-vaccine era. We retrieved and analyzed the incidence and prevalence data for children age 1–14 years in Wenzhou, China during 2010–2018. A cross-sectional seroepidemiology analysis was carried out in a series of 168 general healthy children age 1–14 years as well as children at a varicella outbreak in Wenzhou. Our data showed a significant surge in the incidence and prevalence of varicella in children aged 10–14 years in 2017 and 2018 while they were kept relatively stable in 2010–2016. The seroepidemiological analysis revealed a 7.3-fold significantly higher level of serum varicella IgG in healthy control students who exposed at the outbreak than that in general healthy children (median 523.5 vs. 71.7 mIU/mL, p < .01). The children 10–14 years old had the lowest rate of second-dose vaccination among the three age classes (7%, 41%, and 65% in 10–14, 5–9, and 2–4 age class, respectively), and children 5–9 years old who received the second dose had a higher level of serum protective IgG than those who did not (254.7 vs 98 mIU/mL, p = .06). The findings from the present study warn a two-dose vaccine schedule to reduce the climbing incidence and prevalence observed in the older children and suggest a higher serum IgG threshold for effective protection of children from the varicella outbreak.http://dx.doi.org/10.1080/21645515.2020.1775458varicellavaccineoutbreakprevalenceepidemiologyseroepidemiology |
| spellingShingle | Qi Liu Jiake Yu Jingjiao Wei Hu Zhang Jie Jin Weikun Zheng Yufei Ruan Jinsheng Yu Yiping Chen Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China Human Vaccines & Immunotherapeutics varicella vaccine outbreak prevalence epidemiology seroepidemiology |
| title | Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China |
| title_full | Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China |
| title_fullStr | Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China |
| title_full_unstemmed | Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China |
| title_short | Uptrend prevalence of varicella parallel with low serum antibodies and low second-dose rate among children 10-14 years old in Wenzhou, China |
| title_sort | uptrend prevalence of varicella parallel with low serum antibodies and low second dose rate among children 10 14 years old in wenzhou china |
| topic | varicella vaccine outbreak prevalence epidemiology seroepidemiology |
| url | http://dx.doi.org/10.1080/21645515.2020.1775458 |
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