Oligometastasis: Expansion of Curative Treatments in the Field of Oncology
Oligometastasis is defined as the presence of several limited metastatic lesions and is generally limited to three or fewer than five metastatic lesions. Previously, the treatment of metastatic cancer aimed to alleviate symptoms rather than cure them; however, the use of immunotherapy or targeted th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/11/1934 |
| _version_ | 1797458429323771904 |
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| author | Ah Reum Lim Chai Hong Rim |
| author_facet | Ah Reum Lim Chai Hong Rim |
| author_sort | Ah Reum Lim |
| collection | DOAJ |
| description | Oligometastasis is defined as the presence of several limited metastatic lesions and is generally limited to three or fewer than five metastatic lesions. Previously, the treatment of metastatic cancer aimed to alleviate symptoms rather than cure them; however, the use of immunotherapy or targeted therapy has greatly improved patient life expectancy. Additionally, the effectiveness and safety of local treatment have recently been proven for oligometastatic cancers and have significantly improved patient survival and decreased recurrence rates. A few metastatic studies on lung cancer have demonstrated the usefulness of combining radiation therapy and immunotherapy. Recently, local and targeted therapy combinations have shown promising results in treating non-small cell lung cancer, predominantly caused by the epidermal growth factor receptor and anaplastic lymphoma kinase gene mutations, suggesting the potential of these new treatment strategies. It is well known that oligometastasis has better clinical results than polymetastasis; however, research on the biological profile of oligometastasis is still lacking. Studies using circulating tumor DNA and circulating tumor cells are at the initial stages of providing a better understanding of oligometastatic cancers, and the biological characteristics of these cancers may be revealed based on more diverse studies. With the development of these treatments, the prognosis for patients with oligometastatic cancers is steadily improving, and if the biological profile is revealed, customized treatment may be provided. |
| first_indexed | 2024-03-09T16:37:59Z |
| format | Article |
| id | doaj.art-389afb0c3d014244ba523b84748bfdea |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:37:59Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-389afb0c3d014244ba523b84748bfdea2023-11-24T14:54:44ZengMDPI AGMedicina1010-660X1648-91442023-11-015911193410.3390/medicina59111934Oligometastasis: Expansion of Curative Treatments in the Field of OncologyAh Reum Lim0Chai Hong Rim1Department of Internal Medicine, Division of Oncology, Korea University Ansan Hospital, Korea University, Ansan-si 15355, Republic of KoreaDepartment of Radiation Oncology, Korea University Ansan Hospital, Korea University, Ansan-si 15355, Republic of KoreaOligometastasis is defined as the presence of several limited metastatic lesions and is generally limited to three or fewer than five metastatic lesions. Previously, the treatment of metastatic cancer aimed to alleviate symptoms rather than cure them; however, the use of immunotherapy or targeted therapy has greatly improved patient life expectancy. Additionally, the effectiveness and safety of local treatment have recently been proven for oligometastatic cancers and have significantly improved patient survival and decreased recurrence rates. A few metastatic studies on lung cancer have demonstrated the usefulness of combining radiation therapy and immunotherapy. Recently, local and targeted therapy combinations have shown promising results in treating non-small cell lung cancer, predominantly caused by the epidermal growth factor receptor and anaplastic lymphoma kinase gene mutations, suggesting the potential of these new treatment strategies. It is well known that oligometastasis has better clinical results than polymetastasis; however, research on the biological profile of oligometastasis is still lacking. Studies using circulating tumor DNA and circulating tumor cells are at the initial stages of providing a better understanding of oligometastatic cancers, and the biological characteristics of these cancers may be revealed based on more diverse studies. With the development of these treatments, the prognosis for patients with oligometastatic cancers is steadily improving, and if the biological profile is revealed, customized treatment may be provided.https://www.mdpi.com/1648-9144/59/11/1934oligometastasisimmunotherapytargeted therapyradiation therapysurgeryoligometastatic cancer |
| spellingShingle | Ah Reum Lim Chai Hong Rim Oligometastasis: Expansion of Curative Treatments in the Field of Oncology Medicina oligometastasis immunotherapy targeted therapy radiation therapy surgery oligometastatic cancer |
| title | Oligometastasis: Expansion of Curative Treatments in the Field of Oncology |
| title_full | Oligometastasis: Expansion of Curative Treatments in the Field of Oncology |
| title_fullStr | Oligometastasis: Expansion of Curative Treatments in the Field of Oncology |
| title_full_unstemmed | Oligometastasis: Expansion of Curative Treatments in the Field of Oncology |
| title_short | Oligometastasis: Expansion of Curative Treatments in the Field of Oncology |
| title_sort | oligometastasis expansion of curative treatments in the field of oncology |
| topic | oligometastasis immunotherapy targeted therapy radiation therapy surgery oligometastatic cancer |
| url | https://www.mdpi.com/1648-9144/59/11/1934 |
| work_keys_str_mv | AT ahreumlim oligometastasisexpansionofcurativetreatmentsinthefieldofoncology AT chaihongrim oligometastasisexpansionofcurativetreatmentsinthefieldofoncology |