Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE)
Background: Measurements of urinary dialkyl phosphate (DAP) metabolites are often used to characterize exposures to organophosphate (OP) insecticides; however, some challenges to using urinary DAP metabolites as an exposure measure exist. OP insecticides have short biological half-lives with measure...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021005092 |
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| author | Brittney O. Baumert Nancy Fiedler Tippawan Prapamontol Warangkana Naksen Parinya Panuwet Surat Hongsibsong Anchalee Wongkampaun Nathaporn Thongjan Grace Lee Supattra Sittiwang Chayada Dokjunyam Nattawadee Promkam Sureewan Pingwong Panrapee Suttiwan Wattasit Siriwong P. Barry Ryan Dana Boyd Barr |
| author_facet | Brittney O. Baumert Nancy Fiedler Tippawan Prapamontol Warangkana Naksen Parinya Panuwet Surat Hongsibsong Anchalee Wongkampaun Nathaporn Thongjan Grace Lee Supattra Sittiwang Chayada Dokjunyam Nattawadee Promkam Sureewan Pingwong Panrapee Suttiwan Wattasit Siriwong P. Barry Ryan Dana Boyd Barr |
| author_sort | Brittney O. Baumert |
| collection | DOAJ |
| description | Background: Measurements of urinary dialkyl phosphate (DAP) metabolites are often used to characterize exposures to organophosphate (OP) insecticides; however, some challenges to using urinary DAP metabolites as an exposure measure exist. OP insecticides have short biological half-lives with measurement in a single urine sample typically only reflecting recent exposure within the last few days. Because of the field staff and participant burden of longitudinal sample collection and the high cost of multiple measurements, typically only one or two urine samples have been used to evaluate OP insecticide exposure during pregnancy, which is unlikely to capture an accurate picture of prenatal exposure. Methods: We recruited pregnant farmworker women in Chom Thong and Fang, two districts of Chiang Mai province in northern Thailand (N = 330) into the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) from 2017 to 2019. We collected up to 6 serial urine samples per participant during gestation and composited the samples to represent early, mid, and late pregnancy. We measured concentrations of urinary DAP metabolites in the composited urine samples and evaluated the within- and between-participant variability of these levels. We also investigated predictors of OP insecticide exposure. Results: DAP metabolite concentrations in serial composite samples were weakly to moderately correlated. Spearman correlations indicated that composite urine samples were more highly correlated in Fang participants than in Chom Thong participants. The within-person variances (0.064–0.65) exceeded the between-person variances for DETP, DEP, ∑DEAP, DMP, DMTP, ∑DMAP, ∑DAP. The intraclass correlations (ICCs) for the volume-based individual metabolite levels (ng/mL) ranged from 0.10 to 0.66. For ∑DEAP, ∑DMAP, and ∑DAP the ICCs were, 0.47, 0.17, 0.45 respectively. We observed significant differences between participants from Fang compared to those from Chom Thong both in demographic and exposure characteristics. Spearman correlations of composite samples from Fang participants ranged from 0.55 to 0.66 for the ∑DEAP metabolite concentrations in Fang indicating moderate correlation between pregnancy periods. The ICCs were higher for samples from Fang participants, which drove the overall ICCs. Conclusions: Collecting multiple (∼6) urine samples during pregnancy rather than just 1 or 2 improved our ability to accurately assess exposure during the prenatal period. By compositing the samples, we were able to still obtain trimester-specific information on exposure while keeping the analytic costs and laboratory burden low. This analysis also helped to inform how to best conduct future analyses within the SAWASDEE study. We observed two different exposure profiles in participants in which the concentrations and variability in data were highly linked to the residential location of the participants. |
| first_indexed | 2024-12-22T21:54:13Z |
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| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-22T21:54:13Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-389c703807d7477b963ad20986d4a3692022-12-21T18:11:17ZengElsevierEnvironment International0160-41202022-01-01158106884Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE)Brittney O. Baumert0Nancy Fiedler1Tippawan Prapamontol2Warangkana Naksen3Parinya Panuwet4Surat Hongsibsong5Anchalee Wongkampaun6Nathaporn Thongjan7Grace Lee8Supattra Sittiwang9Chayada Dokjunyam10Nattawadee Promkam11Sureewan Pingwong12Panrapee Suttiwan13Wattasit Siriwong14P. Barry Ryan15Dana Boyd Barr16Emory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USARutgers University, Environmental and Occupational Health Science Institute, Piscataway, NJ, USAChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChiang Mai University, Faculty of Public Health, Chiang Mai, ThailandEmory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USAChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandEmory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USAChiang Mai University, Faculty of Public Health, Chiang Mai, ThailandChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChiang Mai University, Research Institute for Health Sciences, Chiang Mai, ThailandChulalongkorn University, Faculty of Psychology, Bangkok, ThailandChulalongkorn University, College of Public Health Sciences, Bangkok, ThailandEmory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USAEmory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USA; Corresponding author at: Emory University, Rollin School of Public Health, 1518 Clifton Road, Atlanta, GA 30322, USA.Background: Measurements of urinary dialkyl phosphate (DAP) metabolites are often used to characterize exposures to organophosphate (OP) insecticides; however, some challenges to using urinary DAP metabolites as an exposure measure exist. OP insecticides have short biological half-lives with measurement in a single urine sample typically only reflecting recent exposure within the last few days. Because of the field staff and participant burden of longitudinal sample collection and the high cost of multiple measurements, typically only one or two urine samples have been used to evaluate OP insecticide exposure during pregnancy, which is unlikely to capture an accurate picture of prenatal exposure. Methods: We recruited pregnant farmworker women in Chom Thong and Fang, two districts of Chiang Mai province in northern Thailand (N = 330) into the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) from 2017 to 2019. We collected up to 6 serial urine samples per participant during gestation and composited the samples to represent early, mid, and late pregnancy. We measured concentrations of urinary DAP metabolites in the composited urine samples and evaluated the within- and between-participant variability of these levels. We also investigated predictors of OP insecticide exposure. Results: DAP metabolite concentrations in serial composite samples were weakly to moderately correlated. Spearman correlations indicated that composite urine samples were more highly correlated in Fang participants than in Chom Thong participants. The within-person variances (0.064–0.65) exceeded the between-person variances for DETP, DEP, ∑DEAP, DMP, DMTP, ∑DMAP, ∑DAP. The intraclass correlations (ICCs) for the volume-based individual metabolite levels (ng/mL) ranged from 0.10 to 0.66. For ∑DEAP, ∑DMAP, and ∑DAP the ICCs were, 0.47, 0.17, 0.45 respectively. We observed significant differences between participants from Fang compared to those from Chom Thong both in demographic and exposure characteristics. Spearman correlations of composite samples from Fang participants ranged from 0.55 to 0.66 for the ∑DEAP metabolite concentrations in Fang indicating moderate correlation between pregnancy periods. The ICCs were higher for samples from Fang participants, which drove the overall ICCs. Conclusions: Collecting multiple (∼6) urine samples during pregnancy rather than just 1 or 2 improved our ability to accurately assess exposure during the prenatal period. By compositing the samples, we were able to still obtain trimester-specific information on exposure while keeping the analytic costs and laboratory burden low. This analysis also helped to inform how to best conduct future analyses within the SAWASDEE study. We observed two different exposure profiles in participants in which the concentrations and variability in data were highly linked to the residential location of the participants.http://www.sciencedirect.com/science/article/pii/S0160412021005092BiomonitoringOrganophosphateBirth cohortThailandFarmworkers |
| spellingShingle | Brittney O. Baumert Nancy Fiedler Tippawan Prapamontol Warangkana Naksen Parinya Panuwet Surat Hongsibsong Anchalee Wongkampaun Nathaporn Thongjan Grace Lee Supattra Sittiwang Chayada Dokjunyam Nattawadee Promkam Sureewan Pingwong Panrapee Suttiwan Wattasit Siriwong P. Barry Ryan Dana Boyd Barr Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) Environment International Biomonitoring Organophosphate Birth cohort Thailand Farmworkers |
| title | Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) |
| title_full | Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) |
| title_fullStr | Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) |
| title_full_unstemmed | Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) |
| title_short | Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphate pesticides in the Study of Asian Women and their Offspring’s Development and Environmental Exposures (SAWASDEE) |
| title_sort | urinary concentrations of dialkylphosphate metabolites of organophosphate pesticides in the study of asian women and their offspring s development and environmental exposures sawasdee |
| topic | Biomonitoring Organophosphate Birth cohort Thailand Farmworkers |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021005092 |
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