Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment
Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/2/298 |
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| author | Atefeh Zarepour Abdurrahim Can Egil Melike Cokol Cakmak Monireh Esmaeili Rad Yuksel Cetin Seyma Aydinlik Gozde Ozaydin Ince Ali Zarrabi |
| author_facet | Atefeh Zarepour Abdurrahim Can Egil Melike Cokol Cakmak Monireh Esmaeili Rad Yuksel Cetin Seyma Aydinlik Gozde Ozaydin Ince Ali Zarrabi |
| author_sort | Atefeh Zarepour |
| collection | DOAJ |
| description | Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer–Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 °C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against <i>Escherichia coli</i>. Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation. |
| first_indexed | 2024-03-09T11:24:11Z |
| format | Article |
| id | doaj.art-389f25ec82a440a0af239f5588270532 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T11:24:11Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-389f25ec82a440a0af239f55882705322023-12-01T00:07:38ZengMDPI AGPolymers2073-43602023-01-0115229810.3390/polym15020298Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer TreatmentAtefeh Zarepour0Abdurrahim Can Egil1Melike Cokol Cakmak2Monireh Esmaeili Rad3Yuksel Cetin4Seyma Aydinlik5Gozde Ozaydin Ince6Ali Zarrabi7Biomedical Engineering Department, Faculty of Engineering & Natural Sciences, Istinye University, Istanbul 34396, TürkiyeFaculty of Engineering and Natural Sciences, Materials Science and Nano-Engineering Program, Sabanci University, Istanbul 34956, TürkiyeNanotechnology Research and Application Center (SUNUM), Sabanci University, Tuzla 34956, TürkiyeFaculty of Engineering and Natural Sciences, Materials Science and Nano-Engineering Program, Sabanci University, Istanbul 34956, TürkiyeTUBITAK Marmara Research Center, Life Sciences Medical Biotechnology, Gebze 41470, TürkiyeTUBITAK Marmara Research Center, Life Sciences, Industrial Biotechnology, Gebze 41470, TürkiyeFaculty of Engineering and Natural Sciences, Materials Science and Nano-Engineering Program, Sabanci University, Istanbul 34956, TürkiyeBiomedical Engineering Department, Faculty of Engineering & Natural Sciences, Istinye University, Istanbul 34396, TürkiyeChanges in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer–Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 °C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against <i>Escherichia coli</i>. Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation.https://www.mdpi.com/2073-4360/15/2/298niosomeRose Bengaldual responsive nanocarrieranticancerantibacterial |
| spellingShingle | Atefeh Zarepour Abdurrahim Can Egil Melike Cokol Cakmak Monireh Esmaeili Rad Yuksel Cetin Seyma Aydinlik Gozde Ozaydin Ince Ali Zarrabi Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment Polymers niosome Rose Bengal dual responsive nanocarrier anticancer antibacterial |
| title | Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment |
| title_full | Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment |
| title_fullStr | Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment |
| title_full_unstemmed | Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment |
| title_short | Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment |
| title_sort | fabrication of a dual drug loaded smart niosome g chitosan polymeric platform for lung cancer treatment |
| topic | niosome Rose Bengal dual responsive nanocarrier anticancer antibacterial |
| url | https://www.mdpi.com/2073-4360/15/2/298 |
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