Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin
At the micrometric scale, vessels or skin capillaries network architecture can provide useful information for human health management. In this paper, from simulation to in vitro, we investigate some limits and interests of optical feedback interferometry (OFI) for blood flow imaging of skin vascular...
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MDPI AG
2021-02-01
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| author | Adam Quotb Reza Atashkhooei Simone Magaletti Francis Jayat Clement Tronche Julien Goechnahts Julien Perchoux |
| author_facet | Adam Quotb Reza Atashkhooei Simone Magaletti Francis Jayat Clement Tronche Julien Goechnahts Julien Perchoux |
| author_sort | Adam Quotb |
| collection | DOAJ |
| description | At the micrometric scale, vessels or skin capillaries network architecture can provide useful information for human health management. In this paper, from simulation to in vitro, we investigate some limits and interests of optical feedback interferometry (OFI) for blood flow imaging of skin vascularization. In order to analyze the tissue scattering effect on OFI performances, a series of skin-tissue simulating optical phantoms have been designed, fabricated and characterized. The horizontal (2D) and vertical (depth penetration) sensing resolution of the OFI sensor have been estimated. The experimental results that we present on this study are showing a very good accordance with theoretical models. In the case of a skin phantom of 0.5 mm depth with a scattering coefficient from 0 to 10.8 mm<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></semantics></math></inline-formula>, the presented OFI system is able to distinguish a pair of micro fluidic channels (100 µm × 100 µm) spaced by 10 µm. Eventually, an in vivo test on human skin is presented and, for the first time using an OFI sensor, a 2D blood flow image of a vein located just beneath the skin is computed. |
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| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T04:41:46Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-38a0116beb5f44a798f08df9f178fab32023-12-03T13:19:30ZengMDPI AGSensors1424-82202021-02-01214130010.3390/s21041300Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human SkinAdam Quotb0Reza Atashkhooei1Simone Magaletti2Francis Jayat3Clement Tronche4Julien Goechnahts5Julien Perchoux6LAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceCentre for the Development of Sensors, Instruments and Systems, Universitat Politècnica deCatalunya (UPC-CD6), Rambla Sant Nebridi, 10, E08222 Terrassa, SpainLAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, INP-ENSEEIHT, 31400 Toulouse, FranceAt the micrometric scale, vessels or skin capillaries network architecture can provide useful information for human health management. In this paper, from simulation to in vitro, we investigate some limits and interests of optical feedback interferometry (OFI) for blood flow imaging of skin vascularization. In order to analyze the tissue scattering effect on OFI performances, a series of skin-tissue simulating optical phantoms have been designed, fabricated and characterized. The horizontal (2D) and vertical (depth penetration) sensing resolution of the OFI sensor have been estimated. The experimental results that we present on this study are showing a very good accordance with theoretical models. In the case of a skin phantom of 0.5 mm depth with a scattering coefficient from 0 to 10.8 mm<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></semantics></math></inline-formula>, the presented OFI system is able to distinguish a pair of micro fluidic channels (100 µm × 100 µm) spaced by 10 µm. Eventually, an in vivo test on human skin is presented and, for the first time using an OFI sensor, a 2D blood flow image of a vein located just beneath the skin is computed.https://www.mdpi.com/1424-8220/21/4/1300micro scale blood flowimagingoptical feedback interferometry |
| spellingShingle | Adam Quotb Reza Atashkhooei Simone Magaletti Francis Jayat Clement Tronche Julien Goechnahts Julien Perchoux Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin Sensors micro scale blood flow imaging optical feedback interferometry |
| title | Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin |
| title_full | Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin |
| title_fullStr | Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin |
| title_full_unstemmed | Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin |
| title_short | Methods and Limits for Micro Scale Blood Vessel Flow Imaging in Scattering Media by Optical Feedback Interferometry: Application to Human Skin |
| title_sort | methods and limits for micro scale blood vessel flow imaging in scattering media by optical feedback interferometry application to human skin |
| topic | micro scale blood flow imaging optical feedback interferometry |
| url | https://www.mdpi.com/1424-8220/21/4/1300 |
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