Pluronic as nano-carier for drug delivery systems
A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only...
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| Format: | Article |
| Language: | English |
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Iranian Society of Nanomedicine
2018-12-01
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| Series: | Nanomedicine Research Journal |
| Subjects: | |
| Online Access: | http://www.nanomedicine-rj.com/article_33841_b1576cc2aee92abcb722689d25e18a71.pdf |
| _version_ | 1818513410548039680 |
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| author | Abbas Rahdar Susan kazemi Faezeh Askari |
| author_facet | Abbas Rahdar Susan kazemi Faezeh Askari |
| author_sort | Abbas Rahdar |
| collection | DOAJ |
| description | A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such materials is Pluronic block copolymers that cause various functional alterations in cells. The key attribute for the biological activity of Pluronics is their ability to incorporate into membranes followed by subsequent translocation into the cells and affecting various cellular functions, such as mitochondrial respiration, ATP synthesis, activity of drug efflux transporters, apoptotic signal transduction, and gene expression. As a result, Pluronics cause drastic sensitization to various anticancer agents based on multidrug resistant (MDR), enhance drug transport across the blood brain and intestinal barriers, and causes transcriptional activation of gene expression both in vitro and in vivo. On other hand, there has been a considerable research interest in the area of drug delivery using polymer based particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles and micelles have been used as a physical approach to alter and improve the pharmacodynamics and pharmacokinetic profiles of various types of drug molecules. Due to the wide compatibility with drug candidates of diverse nature and ingredients in formulations, poloxamers serve to be excellent polymer for drug delivery vehicles by different routes of administration. This review will highlight the poloxamers-based micelles/nanoparticles that have been developed to date. |
| first_indexed | 2024-12-11T00:00:53Z |
| format | Article |
| id | doaj.art-38a01a416a784b75a959babccdde304c |
| institution | Directory Open Access Journal |
| issn | 2476-3489 2476-7123 |
| language | English |
| last_indexed | 2024-12-11T00:00:53Z |
| publishDate | 2018-12-01 |
| publisher | Iranian Society of Nanomedicine |
| record_format | Article |
| series | Nanomedicine Research Journal |
| spelling | doaj.art-38a01a416a784b75a959babccdde304c2022-12-22T01:28:27ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232018-12-013417417910.22034/nmrj.2018.04.00133841Pluronic as nano-carier for drug delivery systemsAbbas Rahdar0Susan kazemi1Faezeh Askari2Department of Physics, University of Zabol, Zabol, IranM.Sc. of Polymer and Materials Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, IranM.Sc. of Nano-chemistry, Kharazmi University, Tehran, IranA common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such materials is Pluronic block copolymers that cause various functional alterations in cells. The key attribute for the biological activity of Pluronics is their ability to incorporate into membranes followed by subsequent translocation into the cells and affecting various cellular functions, such as mitochondrial respiration, ATP synthesis, activity of drug efflux transporters, apoptotic signal transduction, and gene expression. As a result, Pluronics cause drastic sensitization to various anticancer agents based on multidrug resistant (MDR), enhance drug transport across the blood brain and intestinal barriers, and causes transcriptional activation of gene expression both in vitro and in vivo. On other hand, there has been a considerable research interest in the area of drug delivery using polymer based particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles and micelles have been used as a physical approach to alter and improve the pharmacodynamics and pharmacokinetic profiles of various types of drug molecules. Due to the wide compatibility with drug candidates of diverse nature and ingredients in formulations, poloxamers serve to be excellent polymer for drug delivery vehicles by different routes of administration. This review will highlight the poloxamers-based micelles/nanoparticles that have been developed to date.http://www.nanomedicine-rj.com/article_33841_b1576cc2aee92abcb722689d25e18a71.pdfatpdrug deliverynano carrierpluronic |
| spellingShingle | Abbas Rahdar Susan kazemi Faezeh Askari Pluronic as nano-carier for drug delivery systems Nanomedicine Research Journal atp drug delivery nano carrier pluronic |
| title | Pluronic as nano-carier for drug delivery systems |
| title_full | Pluronic as nano-carier for drug delivery systems |
| title_fullStr | Pluronic as nano-carier for drug delivery systems |
| title_full_unstemmed | Pluronic as nano-carier for drug delivery systems |
| title_short | Pluronic as nano-carier for drug delivery systems |
| title_sort | pluronic as nano carier for drug delivery systems |
| topic | atp drug delivery nano carrier pluronic |
| url | http://www.nanomedicine-rj.com/article_33841_b1576cc2aee92abcb722689d25e18a71.pdf |
| work_keys_str_mv | AT abbasrahdar pluronicasnanocarierfordrugdeliverysystems AT susankazemi pluronicasnanocarierfordrugdeliverysystems AT faezehaskari pluronicasnanocarierfordrugdeliverysystems |