The connectome of the adult Drosophila mushroom body provides insights into function
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently complete...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2020-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/62576 |
| _version_ | 1811181024053297152 |
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| author | Feng Li Jack W Lindsey Elizabeth C Marin Nils Otto Marisa Dreher Georgia Dempsey Ildiko Stark Alexander S Bates Markus William Pleijzier Philipp Schlegel Aljoscha Nern Shin-ya Takemura Nils Eckstein Tansy Yang Audrey Francis Amalia Braun Ruchi Parekh Marta Costa Louis K Scheffer Yoshinori Aso Gregory SXE Jefferis Larry F Abbott Ashok Litwin-Kumar Scott Waddell Gerald M Rubin |
| author_facet | Feng Li Jack W Lindsey Elizabeth C Marin Nils Otto Marisa Dreher Georgia Dempsey Ildiko Stark Alexander S Bates Markus William Pleijzier Philipp Schlegel Aljoscha Nern Shin-ya Takemura Nils Eckstein Tansy Yang Audrey Francis Amalia Braun Ruchi Parekh Marta Costa Louis K Scheffer Yoshinori Aso Gregory SXE Jefferis Larry F Abbott Ashok Litwin-Kumar Scott Waddell Gerald M Rubin |
| author_sort | Feng Li |
| collection | DOAJ |
| description | Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit in Drosophila, including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons. We find unexpected structure in sensory inputs, in the transfer of information about different sensory modalities to MBONs, and in the modulation of that transfer by dopaminergic neurons (DANs). We provide insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs. Our results provide a foundation for further theoretical and experimental work. |
| first_indexed | 2024-04-11T09:11:23Z |
| format | Article |
| id | doaj.art-38a0d0540def4718b12444ab842bda3c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:11:23Z |
| publishDate | 2020-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-38a0d0540def4718b12444ab842bda3c2022-12-22T04:32:29ZengeLife Sciences Publications LtdeLife2050-084X2020-12-01910.7554/eLife.62576The connectome of the adult Drosophila mushroom body provides insights into functionFeng Li0https://orcid.org/0000-0002-6658-9175Jack W Lindsey1https://orcid.org/0000-0003-0930-7327Elizabeth C Marin2https://orcid.org/0000-0001-6333-0072Nils Otto3https://orcid.org/0000-0001-9713-4088Marisa Dreher4https://orcid.org/0000-0002-0041-9229Georgia Dempsey5https://orcid.org/0000-0002-1854-8336Ildiko Stark6Alexander S Bates7https://orcid.org/0000-0002-1195-0445Markus William Pleijzier8https://orcid.org/0000-0002-7297-4547Philipp Schlegel9https://orcid.org/0000-0002-5633-1314Aljoscha Nern10https://orcid.org/0000-0002-3822-489XShin-ya Takemura11https://orcid.org/0000-0003-2400-6426Nils Eckstein12Tansy Yang13https://orcid.org/0000-0003-1131-0410Audrey Francis14https://orcid.org/0000-0003-1974-7174Amalia Braun15Ruchi Parekh16https://orcid.org/0000-0002-8060-2807Marta Costa17https://orcid.org/0000-0001-5948-3092Louis K Scheffer18https://orcid.org/0000-0002-3289-6564Yoshinori Aso19https://orcid.org/0000-0002-2939-1688Gregory SXE Jefferis20https://orcid.org/0000-0002-0587-9355Larry F Abbott21Ashok Litwin-Kumar22https://orcid.org/0000-0003-2422-6576Scott Waddell23https://orcid.org/0000-0003-4503-6229Gerald M Rubin24https://orcid.org/0000-0001-8762-8703Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United StatesDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United KingdomDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom; Centre for Neural Circuits & Behaviour, University of Oxford, Oxford, United KingdomJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United KingdomDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United KingdomNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United KingdomNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United KingdomDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United KingdomJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United KingdomJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United KingdomJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United KingdomDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United StatesDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United StatesCentre for Neural Circuits & Behaviour, University of Oxford, Oxford, United KingdomJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesMaking inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit in Drosophila, including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons. We find unexpected structure in sensory inputs, in the transfer of information about different sensory modalities to MBONs, and in the modulation of that transfer by dopaminergic neurons (DANs). We provide insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs. Our results provide a foundation for further theoretical and experimental work.https://elifesciences.org/articles/62576dopaminelearningmemoryneuronal circuitsbehavior |
| spellingShingle | Feng Li Jack W Lindsey Elizabeth C Marin Nils Otto Marisa Dreher Georgia Dempsey Ildiko Stark Alexander S Bates Markus William Pleijzier Philipp Schlegel Aljoscha Nern Shin-ya Takemura Nils Eckstein Tansy Yang Audrey Francis Amalia Braun Ruchi Parekh Marta Costa Louis K Scheffer Yoshinori Aso Gregory SXE Jefferis Larry F Abbott Ashok Litwin-Kumar Scott Waddell Gerald M Rubin The connectome of the adult Drosophila mushroom body provides insights into function eLife dopamine learning memory neuronal circuits behavior |
| title | The connectome of the adult Drosophila mushroom body provides insights into function |
| title_full | The connectome of the adult Drosophila mushroom body provides insights into function |
| title_fullStr | The connectome of the adult Drosophila mushroom body provides insights into function |
| title_full_unstemmed | The connectome of the adult Drosophila mushroom body provides insights into function |
| title_short | The connectome of the adult Drosophila mushroom body provides insights into function |
| title_sort | connectome of the adult drosophila mushroom body provides insights into function |
| topic | dopamine learning memory neuronal circuits behavior |
| url | https://elifesciences.org/articles/62576 |
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