Correlation between activation of PI3K/AKT/mTOR pathway and prognosis of breast cancer in Chinese women.

Correlation between activation of PI3K/AKT/mTOR pathway and prognosis of breast cancer in Chinese women.

Abnormal activation of PI3K/AKT/mTOR (PAM) pathway, caused by PIK3CA mutation, KRAS mutation, PTEN loss, or AKT1 mutation, is one of the most frequent signaling abnormalities in breast carcinoma. However, distribution and frequencies of mutations in PAM pathway are unclear in breast cancer patients...

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Bibliographic Details
Main Authors: Ling Deng, Jie Chen, Xiao Rong Zhong, Ting Luo, Yan Ping Wang, Hui Fen Huang, Li-Juan Yin, Yan Qiu, Hong Bu, Qing Lv, Hong Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4376391?pdf=render

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