Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval
Altered fear learning is a strong behavioral component of anxiety disorders such as post-traumatic stress disorder (PTSD). Recent efforts have attempted to combine exposure therapies with drugs that target fear memory retrieval and memory reconsolidation, in order to improve treatment efficacy. The...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.919831/full |
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| author | Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Briana K. Chen Guilherme R. Pereira Guilherme R. Pereira Vananh Pham Vananh Pham Christine A. Denny Christine A. Denny |
| author_facet | Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Briana K. Chen Guilherme R. Pereira Guilherme R. Pereira Vananh Pham Vananh Pham Christine A. Denny Christine A. Denny |
| author_sort | Sofia Leal Santos |
| collection | DOAJ |
| description | Altered fear learning is a strong behavioral component of anxiety disorders such as post-traumatic stress disorder (PTSD). Recent efforts have attempted to combine exposure therapies with drugs that target fear memory retrieval and memory reconsolidation, in order to improve treatment efficacy. The noradrenergic (NA) signaling system is of particular interest, due to its role in regulating the stress response and its involvement in fear and learning processes. Importantly, propranolol (P), a non-selective β-adrenergic antagonist, has shown the potential in decreasing exaggerated fear in both humans and animal models. In a previous study, we utilized an activity-dependent tagging murine model to determine the neural mechanisms by which propranolol attenuates learned fear. We found that propranolol acutely decreased memory trace reactivation specifically in the dorsal dentate gyrus (dDG), but not in CA3 or CA1. Here, we extended our previous study by investigating whether propranolol additionally altered activity in the hilus, a polymorphic layer that consists of neurons, mossy cells, and GABAergic interneurons. We found that propranolol acutely reduced overall hilar activity in both the dorsal and ventral hilus. Moreover, we report that propranolol significantly altered the activity of parvalbumin (PV)+ cells in the ventral (vDG), but not dorsal DG (dDG). Together, these results suggest that a β-adrenergic blockade may affect the activity of excitatory and inhibitory cell types in the hilar layer of the DG, and that these alterations may contribute to manipulating fear memory traces. |
| first_indexed | 2024-04-13T21:22:57Z |
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| id | doaj.art-38a337a5aa46487aab6c7ada2a164e1f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T21:22:57Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-38a337a5aa46487aab6c7ada2a164e1f2022-12-22T02:29:25ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-07-011610.3389/fnbeh.2022.919831919831Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear RetrievalSofia Leal Santos0Sofia Leal Santos1Sofia Leal Santos2Sofia Leal Santos3Briana K. Chen4Guilherme R. Pereira5Guilherme R. Pereira6Vananh Pham7Vananh Pham8Christine A. Denny9Christine A. Denny10Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, United StatesDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH)/New York State Psychiatric Institute (NYSPI), New York, NY, United StatesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalInstituto de Investigação em Ciências da Vida e da Saúde (ICVS)/3Bs - PT Government Associate Laboratory, Guimarães, PortugalNeurobiology and Behavior (NB&B) Graduate Program, Columbia University, New York, NY, United StatesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalInstituto de Investigação em Ciências da Vida e da Saúde (ICVS)/3Bs - PT Government Associate Laboratory, Guimarães, PortugalDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, United StatesDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH)/New York State Psychiatric Institute (NYSPI), New York, NY, United StatesDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, United StatesDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH)/New York State Psychiatric Institute (NYSPI), New York, NY, United StatesAltered fear learning is a strong behavioral component of anxiety disorders such as post-traumatic stress disorder (PTSD). Recent efforts have attempted to combine exposure therapies with drugs that target fear memory retrieval and memory reconsolidation, in order to improve treatment efficacy. The noradrenergic (NA) signaling system is of particular interest, due to its role in regulating the stress response and its involvement in fear and learning processes. Importantly, propranolol (P), a non-selective β-adrenergic antagonist, has shown the potential in decreasing exaggerated fear in both humans and animal models. In a previous study, we utilized an activity-dependent tagging murine model to determine the neural mechanisms by which propranolol attenuates learned fear. We found that propranolol acutely decreased memory trace reactivation specifically in the dorsal dentate gyrus (dDG), but not in CA3 or CA1. Here, we extended our previous study by investigating whether propranolol additionally altered activity in the hilus, a polymorphic layer that consists of neurons, mossy cells, and GABAergic interneurons. We found that propranolol acutely reduced overall hilar activity in both the dorsal and ventral hilus. Moreover, we report that propranolol significantly altered the activity of parvalbumin (PV)+ cells in the ventral (vDG), but not dorsal DG (dDG). Together, these results suggest that a β-adrenergic blockade may affect the activity of excitatory and inhibitory cell types in the hilar layer of the DG, and that these alterations may contribute to manipulating fear memory traces.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.919831/fullhippocampushilusArcFossomatostatinparvalbumin |
| spellingShingle | Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Sofia Leal Santos Briana K. Chen Guilherme R. Pereira Guilherme R. Pereira Vananh Pham Vananh Pham Christine A. Denny Christine A. Denny Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval Frontiers in Behavioral Neuroscience hippocampus hilus Arc Fos somatostatin parvalbumin |
| title | Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval |
| title_full | Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval |
| title_fullStr | Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval |
| title_full_unstemmed | Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval |
| title_short | Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval |
| title_sort | propranolol administration modulates neural activity in the hippocampal hilus during fear retrieval |
| topic | hippocampus hilus Arc Fos somatostatin parvalbumin |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.919831/full |
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