New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
Abstract Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are need...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-017-1454-2 |
| _version_ | 1811333509565906944 |
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| author | Heng Li Dan Wang Yongjian Yuan Jikang Min |
| author_facet | Heng Li Dan Wang Yongjian Yuan Jikang Min |
| author_sort | Heng Li |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are needed for diagnosing and monitoring the progression of OA during its early stages when therapeutic drugs or biological agents are most likely to be effective. Various proteinases involved in articular cartilage degeneration in pre-OA conditions, which may represent the earliest reversible measurable changes, are considered diagnostic and therapeutic targets for early OA. Of these proteinases, matrix metalloproteinase 13 (MMP-13) has received the most attention, because it is a central node in the cartilage degradation network. In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. Moreover, the various entities mentioned in this review might be useful as early biomarkers and for personalized approaches to disease prevention and treatment by improving the phenotyping of early OA patients. |
| first_indexed | 2024-04-13T16:52:44Z |
| format | Article |
| id | doaj.art-38a69a8ed7e54758bc7f80c62c6b200a |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-13T16:52:44Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-38a69a8ed7e54758bc7f80c62c6b200a2022-12-22T02:38:53ZengBMCArthritis Research & Therapy1478-63622017-11-0119111210.1186/s13075-017-1454-2New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritisHeng Li0Dan Wang1Yongjian Yuan2Jikang Min3The First Affiliated Hospital of Huzhou Teachers CollegeThe First Affiliated Hospital of Huzhou Teachers CollegeThe First Affiliated Hospital of Huzhou Teachers CollegeThe First Affiliated Hospital of Huzhou Teachers CollegeAbstract Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are needed for diagnosing and monitoring the progression of OA during its early stages when therapeutic drugs or biological agents are most likely to be effective. Various proteinases involved in articular cartilage degeneration in pre-OA conditions, which may represent the earliest reversible measurable changes, are considered diagnostic and therapeutic targets for early OA. Of these proteinases, matrix metalloproteinase 13 (MMP-13) has received the most attention, because it is a central node in the cartilage degradation network. In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. Moreover, the various entities mentioned in this review might be useful as early biomarkers and for personalized approaches to disease prevention and treatment by improving the phenotyping of early OA patients.http://link.springer.com/article/10.1186/s13075-017-1454-2Matrix metalloproteinasesMMP-13OsteoarthritisNon-coding RNADNA methylationAutophagy |
| spellingShingle | Heng Li Dan Wang Yongjian Yuan Jikang Min New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis Arthritis Research & Therapy Matrix metalloproteinases MMP-13 Osteoarthritis Non-coding RNA DNA methylation Autophagy |
| title | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| title_full | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| title_fullStr | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| title_full_unstemmed | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| title_short | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| title_sort | new insights on the mmp 13 regulatory network in the pathogenesis of early osteoarthritis |
| topic | Matrix metalloproteinases MMP-13 Osteoarthritis Non-coding RNA DNA methylation Autophagy |
| url | http://link.springer.com/article/10.1186/s13075-017-1454-2 |
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