A microfluidic chip-based co-culture of fibroblast-like synoviocytes with osteoblasts and osteoclasts to test bone erosion and drug evaluation

A microfluidic chip-based co-culture of fibroblast-like synoviocytes with osteoblasts and osteoclasts to test bone erosion and drug evaluation

Targeting fibroblast-like synoviocyte (FLS) migration and invasion-mediated bone erosion is a promising clinical strategy for the treatment of rheumatoid arthritis (RA). Drug sensitivity testing is fundamental to this scheme. We designed a microfluidic chip-based, cell co-cultured platform to mimic...

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Bibliographic Details
Main Authors: Hui-Peng Ma, Xue Deng, Deng-Yi Chen, Di Zhu, Jin-Ling Tong, Ting Zhao, Jin-Hui Ma, Yan-Qiu Liu
Format: Article
Language:English
Published: The Royal Society 2018-01-01
Series:Royal Society Open Science
Subjects:
microfluidic chip
fibroblast-like synoviocytes
bone marrow mesenchymal stem cells
osteoclast
migration
bone erosion
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180528

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