Metalloproteinases in Cardiac Surgery: A Systematic Review
The role of matrix metalloproteinases (MMPs) in routine cardiac operations including cardiopulmonary bypass (CPB) is still poorly explored. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of the MMP profile in cardiac surgery. All studies meeting...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/113 |
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| author | Giuseppe Filiberto Serraino Federica Jiritano Davide Costa Nicola Ielapi Domenica Battaglia Umberto Marcello Bracale Pasquale Mastroroberto Michele Andreucci Raffaele Serra |
| author_facet | Giuseppe Filiberto Serraino Federica Jiritano Davide Costa Nicola Ielapi Domenica Battaglia Umberto Marcello Bracale Pasquale Mastroroberto Michele Andreucci Raffaele Serra |
| author_sort | Giuseppe Filiberto Serraino |
| collection | DOAJ |
| description | The role of matrix metalloproteinases (MMPs) in routine cardiac operations including cardiopulmonary bypass (CPB) is still poorly explored. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of the MMP profile in cardiac surgery. All studies meeting the inclusion criteria (i.e., those reporting detailed data about MMP release during and after CPB) were selected after screening the literature published between July 1975 and August 2022. Fifteen trials that enrolled a total of 431 participants were included. MMP levels were found to be significantly correlated with CPB in all included studies. The gelatinases MMP-2 and MMP-9 were highly released in cardiac surgery with CPB. MMP-9 levels were found to be increased after CPB start and during the duration of CPB. Particularly, it is overexpressed both in the myocardial tissue and circulating in the bloodstream. Also, MMP-2 levels increased after CPB both in plasma and in myocardial tissue. MMP-7, MMP-8, and MMP-13 levels increased after CPB start and remained elevated up to 6 h later. Increased levels of MMPs were associated with adverse post-operative outcomes. Conversely, TIMP-1 decreased with CPB. Mechanical and pharmacological strategies were applied in two studies to analyze their effect on the inflammatory response to cardiac surgery and CPB and on postoperative outcomes. New targeted MMP inhibitor therapies could protect against systemic inflammatory response syndrome after CPB and should be the subject of future large prospective multicenter randomized clinical trials. |
| first_indexed | 2024-03-09T13:27:04Z |
| format | Article |
| id | doaj.art-38a96293d9644488873ceb35456447b1 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:04Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-38a96293d9644488873ceb35456447b12023-11-30T21:22:57ZengMDPI AGBiomolecules2218-273X2023-01-0113111310.3390/biom13010113Metalloproteinases in Cardiac Surgery: A Systematic ReviewGiuseppe Filiberto Serraino0Federica Jiritano1Davide Costa2Nicola Ielapi3Domenica Battaglia4Umberto Marcello Bracale5Pasquale Mastroroberto6Michele Andreucci7Raffaele Serra8Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Law, Economics and Sociology, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Department of Surgical and Medical Sciences, University “Magna Graecia” of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Public Health, University Federico II of Naples, 80138 Naples, ItalyDepartment of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Department of Surgical and Medical Sciences, University “Magna Graecia” of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyThe role of matrix metalloproteinases (MMPs) in routine cardiac operations including cardiopulmonary bypass (CPB) is still poorly explored. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of the MMP profile in cardiac surgery. All studies meeting the inclusion criteria (i.e., those reporting detailed data about MMP release during and after CPB) were selected after screening the literature published between July 1975 and August 2022. Fifteen trials that enrolled a total of 431 participants were included. MMP levels were found to be significantly correlated with CPB in all included studies. The gelatinases MMP-2 and MMP-9 were highly released in cardiac surgery with CPB. MMP-9 levels were found to be increased after CPB start and during the duration of CPB. Particularly, it is overexpressed both in the myocardial tissue and circulating in the bloodstream. Also, MMP-2 levels increased after CPB both in plasma and in myocardial tissue. MMP-7, MMP-8, and MMP-13 levels increased after CPB start and remained elevated up to 6 h later. Increased levels of MMPs were associated with adverse post-operative outcomes. Conversely, TIMP-1 decreased with CPB. Mechanical and pharmacological strategies were applied in two studies to analyze their effect on the inflammatory response to cardiac surgery and CPB and on postoperative outcomes. New targeted MMP inhibitor therapies could protect against systemic inflammatory response syndrome after CPB and should be the subject of future large prospective multicenter randomized clinical trials.https://www.mdpi.com/2218-273X/13/1/113matrix metalloproteinasescardiopulmonary bypasscardiac surgeryinflammationSIRS |
| spellingShingle | Giuseppe Filiberto Serraino Federica Jiritano Davide Costa Nicola Ielapi Domenica Battaglia Umberto Marcello Bracale Pasquale Mastroroberto Michele Andreucci Raffaele Serra Metalloproteinases in Cardiac Surgery: A Systematic Review Biomolecules matrix metalloproteinases cardiopulmonary bypass cardiac surgery inflammation SIRS |
| title | Metalloproteinases in Cardiac Surgery: A Systematic Review |
| title_full | Metalloproteinases in Cardiac Surgery: A Systematic Review |
| title_fullStr | Metalloproteinases in Cardiac Surgery: A Systematic Review |
| title_full_unstemmed | Metalloproteinases in Cardiac Surgery: A Systematic Review |
| title_short | Metalloproteinases in Cardiac Surgery: A Systematic Review |
| title_sort | metalloproteinases in cardiac surgery a systematic review |
| topic | matrix metalloproteinases cardiopulmonary bypass cardiac surgery inflammation SIRS |
| url | https://www.mdpi.com/2218-273X/13/1/113 |
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