In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents

In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents

Novel spiro acenaphthylene pyrrolo[1,2-b]isoquinoline/pyrrolidine hybrids have been achieved through Pictet-Spengler/Eschweiler-Clarke reactions depending on the substitution in the benzyl ring. The in vitro biological efficacy of N-methyl spiropyrrolidine derivatives toward different cancer and non...

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Bibliographic Details
Main Authors: Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Faruq Mohammad, Raju Ranjith Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Chemistry
Subjects:
molecular biology
in vitro studies
role of caspases
spiropyrrolidine hybrid heterocycles
N-methylation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00465/full

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