Deletion of Kvβ2 (AKR6) Attenuates Isoproterenol Induced Cardiac Injury with Links to Solute Carrier Transporter SLC41a3 and Circadian Clock Genes

Deletion of Kvβ2 (AKR6) Attenuates Isoproterenol Induced Cardiac Injury with Links to Solute Carrier Transporter SLC41a3 and Circadian Clock Genes

Kvβ subunits belong to the aldo-keto reductase superfamily, which plays a significant role in ion channel regulation and modulates the physiological responses. However, the role of Kvβ2 in cardiac pathophysiology was not studied, and therefore, in the present study, we hypothesized that Kvβ2 plays a...

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Bibliographic Details
Main Authors: Jared Tur, Kalyan C. Chapalamadagu, Ravikumar Manickam, Feng Cheng, Srinivas M. Tipparaju
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Metabolites
Subjects:
Kvβ subunit
redox
potassium channel
heart
aldo-keto reductase
pyridine nucleotides
Online Access:https://www.mdpi.com/2218-1989/11/4/201

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