Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite
Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/6/932 |
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| author | Simonida Lj. Tomić Jasmina Nikodinović-Runić Marija Vukomanović Marija M. Babić Jovana S. Vuković |
| author_facet | Simonida Lj. Tomić Jasmina Nikodinović-Runić Marija Vukomanović Marija M. Babić Jovana S. Vuković |
| author_sort | Simonida Lj. Tomić |
| collection | DOAJ |
| description | Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material’s composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration. |
| first_indexed | 2024-03-10T13:07:34Z |
| format | Article |
| id | doaj.art-38ac6e47c45f4845847cf6f0fceb190f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T13:07:34Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-38ac6e47c45f4845847cf6f0fceb190f2023-11-21T10:57:51ZengMDPI AGPolymers2073-43602021-03-0113693210.3390/polym13060932Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and HydroxyapatiteSimonida Lj. Tomić0Jasmina Nikodinović-Runić1Marija Vukomanović2Marija M. Babić3Jovana S. Vuković4Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000 Belgrade, SerbiaAdvanced Materials Department, Jožef Stefan Institute, Jamova Cesta 39, 1000 Ljubljana, SloveniaFaculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, SerbiaFaculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, SerbiaHydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material’s composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.https://www.mdpi.com/2073-4360/13/6/932alginate/gelatin/2-hydroxyethyl methacrylate/hydroxyapatitehydrogel scaffolding biomaterialdegradable scaffoldsbiocompatibilitytissue regeneration engineering |
| spellingShingle | Simonida Lj. Tomić Jasmina Nikodinović-Runić Marija Vukomanović Marija M. Babić Jovana S. Vuković Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite Polymers alginate/gelatin/2-hydroxyethyl methacrylate/hydroxyapatite hydrogel scaffolding biomaterial degradable scaffolds biocompatibility tissue regeneration engineering |
| title | Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite |
| title_full | Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite |
| title_fullStr | Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite |
| title_full_unstemmed | Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite |
| title_short | Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite |
| title_sort | novel hydrogel scaffolds based on alginate gelatin 2 hydroxyethyl methacrylate and hydroxyapatite |
| topic | alginate/gelatin/2-hydroxyethyl methacrylate/hydroxyapatite hydrogel scaffolding biomaterial degradable scaffolds biocompatibility tissue regeneration engineering |
| url | https://www.mdpi.com/2073-4360/13/6/932 |
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