Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies
Liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is increasing in incidence and mortality across the globe. An improved understanding of the complex tumor microenvironment has opened many therapeutic doors and led to the development of novel pharmaceuticals targe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/9/2624 |
| _version_ | 1797602831106048000 |
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| author | Jonathan Charles Andrea Vrionis Arian Mansur Trevor Mathias Jamil Shaikh Aaron Ciner Yixing Jiang Nariman Nezami |
| author_facet | Jonathan Charles Andrea Vrionis Arian Mansur Trevor Mathias Jamil Shaikh Aaron Ciner Yixing Jiang Nariman Nezami |
| author_sort | Jonathan Charles |
| collection | DOAJ |
| description | Liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is increasing in incidence and mortality across the globe. An improved understanding of the complex tumor microenvironment has opened many therapeutic doors and led to the development of novel pharmaceuticals targeting cellular signaling pathways or immune checkpoints. These interventions have significantly improved tumor control rates and patient outcomes, both in clinical trials and in real-world practice. Interventional radiologists play an important role in the multidisciplinary team given their expertise in minimally invasive locoregional therapy, as the bulk of these tumors are usually in the liver. The aim of this review is to highlight the immunological therapeutic targets for primary liver cancers, the available immune-based approaches, and the contributions that interventional radiology can provide in the care of these patients. |
| first_indexed | 2024-03-11T04:22:04Z |
| format | Article |
| id | doaj.art-38acbb86d5c44ae8bcd505485a58fe08 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:22:04Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-38acbb86d5c44ae8bcd505485a58fe082023-11-17T22:42:19ZengMDPI AGCancers2072-66942023-05-01159262410.3390/cancers15092624Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related MalignanciesJonathan Charles0Andrea Vrionis1Arian Mansur2Trevor Mathias3Jamil Shaikh4Aaron Ciner5Yixing Jiang6Nariman Nezami7Morsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USAMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USAHarvard Medical School, Harvard University, Boston, MA 02115, USASchool of Medicine, University of Maryland, Baltimore, MD 21201, USAMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USADepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USADivision of Vascular and Interventional Radiology, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USALiver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is increasing in incidence and mortality across the globe. An improved understanding of the complex tumor microenvironment has opened many therapeutic doors and led to the development of novel pharmaceuticals targeting cellular signaling pathways or immune checkpoints. These interventions have significantly improved tumor control rates and patient outcomes, both in clinical trials and in real-world practice. Interventional radiologists play an important role in the multidisciplinary team given their expertise in minimally invasive locoregional therapy, as the bulk of these tumors are usually in the liver. The aim of this review is to highlight the immunological therapeutic targets for primary liver cancers, the available immune-based approaches, and the contributions that interventional radiology can provide in the care of these patients.https://www.mdpi.com/2072-6694/15/9/2624immunotherapyhepatocellular carcinomaintrahepatic cholangiocarcinomainterventional radiologyinterventional oncology |
| spellingShingle | Jonathan Charles Andrea Vrionis Arian Mansur Trevor Mathias Jamil Shaikh Aaron Ciner Yixing Jiang Nariman Nezami Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies Cancers immunotherapy hepatocellular carcinoma intrahepatic cholangiocarcinoma interventional radiology interventional oncology |
| title | Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies |
| title_full | Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies |
| title_fullStr | Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies |
| title_full_unstemmed | Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies |
| title_short | Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies |
| title_sort | potential immunotherapy targets for liver directed therapies and the current scope of immunotherapeutics for liver related malignancies |
| topic | immunotherapy hepatocellular carcinoma intrahepatic cholangiocarcinoma interventional radiology interventional oncology |
| url | https://www.mdpi.com/2072-6694/15/9/2624 |
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